Fig3. (A) Thioflavine S staining of WT and hAPPNL-G-F mice at 1, 3 and 6 months (magnification, 40x and 100x). (B) Statistics of ThiS positive plaque area. 相关品系 Iapp-KO(2) 品系名:C57BL/6Smoc-Iappem3Smoc 品系状态:精子冻存 | 目录号:NM-KO-251268 ...
The results show a large panel of inflammatory mediators, leptin, and other proteins that may be involved in weakening the blood brain barrier, to be increased in the young App NL-G-F mice but not in the old AppNL-G-F mice. There were also several differentially expressed genes in both...
We also found reductions in amyloid load and microgliosis, and a preservation of cholinergic cells in the brain of APPNL-G-F mice allowed to exercise in their home cages. These profound reductions in brain pathology associated with AD are likely responsible for the observed improvement of ...
CSF1R inhibitor abrogates tau propagation exacerbated in APPNL‐G‐F knock‐in mice but enhances fibrillar beta‐amyloidosis and dystrophic neurite formation in the brainMicroglia are the primary innate immune cells in the brain. They can phagocytose apoptotic neurons and dystrophic neurites containing...
We combined the cognitive assessment of these mice with histological analyses and full transcriptional and protein quantification profiling of the hippocampus. Additionally, we derived specific Aβ-related molecular AD signatures and looked for drugs able to globally revert them. Results We found that ...
Spatial analyses suggested that activated microglia were more closely associated with amyloid-β oligomers than with amyloid-β plaques in AppNL-G-F mice, which also showed age-dependent decreases in neuronal and synaptic density markers. A comparative study of the two models highlighted the ...
We combined the cognitive assessment of these mice with histological analyses and full transcriptional and protein quantification profiling of the hippocampus. Additionally, we derived specific Aβ-related molecular AD signatures and looked for drugs able to globally revert them. Results We found that ...
mice contain one or more mutations that shift the balance of the APP processing pathway towards the formation of Aβ40and Aβ42fragments [15]. The APP-KI mouse model family contains mice that exhibit heterozygous and homozygous combinations of 3 mutations associated with amyloid pathology ...
将小鼠App基因全部或者部分替换为人源AppNL-G-F,从而表达人或人鼠嵌合AppNL-G-F蛋白,取代小鼠内源App蛋白的表达。 应用领域:老年痴呆AD相关人源化小鼠模型 *使用本品系发表的文献需注明: hAppNL-G-F mice (Cat. NO. NM-HU-2000088) were purchased from Shanghai Model Organisms Center, Inc.. 验证...
Results Structural spine plasticity is already impaired in CA1 neurons in untreated AppNL-G-F mice of this early age. Interestingly, prolonged high-dose but not low-dose BACE1-inhibition was found to enhance spine formation and did not cause spine loss as observed in wildtype control mice. ...