APOPTOSISRNAGENE expressionTUMOR necrosis factorsCHEMOKINESObjectives: This study was carried out to compare the expression levels of ASC(Apoptosis Associated Speck Like Protein Containing a CARD), TL-1a(TNF Like Factor 1a) and CXCL 13(B Cell Chemoattractant Chemokine Ligand 13) genes in...
Apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) is a key adaptor protein of inflammasomes and a proapoptotic molecule; however, its roles in signal transduction in pancreatic ductal adenocarcinoma (PDAC) cells remain unknown. Here, we clarified the role and mechan...
Apoptosis-related speck-like protein (ASC) is a key adapter protein in many inflammasome protein complexes, which mediates inflammation and host defense. In this study, an ASC gene (named Msasc) was identified and cloned from the liver tissue of Micropterus salmoides. The full-length cDNA seque...
Apoptosis-associated speck-like protein containing a CARD(ASC) is an adaptor protein that has a bipartite domain structure,an N-terminal pyrin domain(PYD) and a C-terminal caspase recruitment domain(CARD).Recent researches demonstrate that ASC plays an important role in many signal pathways by it...
The apoptosis-associated Speck-like protein containing a caspase-1 recruitment domain (ASC), present in inflammasomes, regulates inflammation events and is involved in osteogenic phenotype. Nevertheless, its function in bone repair induced by bone substitute biomaterials is unclear. This study aimed to ...
Pyrin, the protein product of the FMF gene MEFV, interacts with the inflammasome complex adaptor protein ASC/PYCARD (apoptosis-associated speck-like protein with a CARD). Pyrin and ASC can both function as either inducers or suppressors of the cellular inflammatory response. We aimed to ...
The role of apoptosis゛ssociated speck﹍ike protein containing a caspaserecruitment domain (ASC) in bone healing remains to be understood. To address this issue, we investigated the requirement of inflammasome‐related genes in response to bone morphogenetic protein 7 (BMP7)﹊nduced osteoblast ...
Apoptosis-associated speck-like protein containing a CARD (ASC) expression profiles in familial Mediterranean fever (FMF) patients with different MEFV mutation patterns. Scand J Rheumatol (2013) 42:159-62. doi:10.3109/03009742.2012.699551Nalbantoglu, S., Tanyolac, B., Berdeli, A. (2013). ...
2010 . Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC) regulates inflammasomes. J Inflamm (Lond) 7:23.Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC) regulates inflammasomes...
Studies have shown that inflammasomes play an important role in the inflammation following SCI, and apoptosis-associated speck-like protein containing a card (ASC) is the adaptor protein shared by inflammasomes. Therefore, we speculated that inhibiting ASC may improve the local microenvironment of ...