1. Introduction: an overview of programmed cell death (PCD) Apoptotic cell death is a genetically programmed mechanism(s) that allows the cell to commit suicide [1], [2], [3], [4]. Apoptosis is critically important for the survival of multicellular organisms by getting rid of damaged or ...
Apoptosis, or programmed cell death, is a conserved and highly regulated pathway by which cells die. Apoptosis can be triggered when cells encounter a wide range of cytotoxic stresses. These insults initiate signaling cascades that ultimately cause the release of cytochrome c from the mitochondrial ...
Apoptosis is a genetically determined mode of cell death that relies on energy-dependent cascade of caspase-mediated molecular events.1,2,3,4,5It is important for natural cell turnover during development and aging, and in the elimination of virus-infected and damaged cells. It is of clinical ...
It is unclear what effect the chromatin released from dying tumor cells might have. To study this, we treated 4T1 cells with a variety of cell death-inducing reagents (Supplementary Table 1) and performed time-lapse imaging using H2B:GFP to mark the chromatin. We observed a phenotype ...
One of the earliest structural changes in the dying cell is widespread chromatin condensation, of the type characteristic of apoptosis, the mode of death frequently observed where cell deletion seems to be `programmed'. It is shown here that this morphological change is closely associated with ...
Apoptosis is a well defined physiological process characterised by many specific features including DNA fragmentation and protease activation. Cell membrane-associated changes such as the altered exposure of phosphatidylserine and glycosylation patterns have also been described. We investigate here the change ...
Apoptosis is also regulated by B cell lymphoma 2 (Bcl-2) family members, which control mitochondrial outer membrane permeabilization (MOMP)15,16. This family contains pro- and anti-apoptotic proteins that can form complexes via a common BH3 domain15,17,18,19,20. Importantly, high levels of...
wherein Ar 1 , R 2 , A, B and D are defined herein. The present invention relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce...
These studies suggest that OGD of cultured cortical cells models the excitotoxic, but not the apoptotic component of cell death observed in vivo. This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 digital issues and online ...
Transcription of essentially the entire eukaryotic genome generates a myriad of non-protein-... CP Ponting,PL Oliver,W Reik - 《Cell》 被引量: 4831发表: 2009年 【Ln-x18A】Evolution and functions of long noncoding RNAs. RNA is not only a messenger operating between DNA and protein. ...