Apoptosis: Telling cells their time is up 来自 Elsevier 喜欢 0 阅读量: 35 作者: S Nagata 摘要: Ligand engagement by the receptor Fas leads to apoptosis. A clue to how this happens comes from the discovery that ligand binding leads to recruitment to Fas of a protease, homologous to ...
It is unclear what effect the chromatin released from dying tumor cells might have. To study this, we treated 4T1 cells with a variety of cell death-inducing reagents (Supplementary Table 1) and performed time-lapse imaging using H2B:GFP to mark the chromatin. We observed a phenotype ...
Apoptosis is a form of programmed cell death that results in the orderly and efficient removal of damaged cells to ensure a homeostatic balance between the rate of cell formation and cell death. However, the disruption of this balancing function can contribute to an abnormal cell growth/proliferati...
Defects in both apoptotic and non-apoptotic cell-death pathways are strictly associated with tumorigenesis. In particular, resistance to apoptosis is considered to be an hallmark of cancer cells. Defects in apoptosis underlie not only tumorigenesis, but
anot to advanced is go to back 不对先进是去支持 [translate] adouble staining. Bcl-2 was detected in Fas:APO 1 expressing plaques. A number of CD3-positive T-lymphocytes were found [translate] amonoclonal antibody. Apoptotic cells were stained in situ by terminal deoxynucleotidyl transferase ...
What do we mean when we write "senescence,""apoptosis," "necrosis," or "clearance of dying cells"? Zazoun J, Tabib A, Grau A, Verbovetski-Reiner I: What do we mean when we write "senescence,""apoptosis,""necrosis," or "clearance of dying cells... D Mevorach,U Trahtemberg,A ...
Furthermore, electron microscopy revealed that peribiliary fibrogenic cells from WT mice also had a dedifferentiated (immature) synthetic myofibroblast-like phenotype, containing a significantly larger number of cell organelles (Supplemental Figure S4). This is similar to the migrating intimal smooth ...
Studies have demonstrated that Cd can induce apoptosis in neuronal cells. The CD95/APO-1 (Fas)/Fas Ligand (FasL) signaling pathway is one of the primary apoptosis pathways, but the role and regulatory mechanism of this pathway in neuronal cells remain unclear. Here, we demonstrated the ...
As p53 mutations are exceedingly rare in neuroblastomas13,14, it may be that p73 acts as a p53-like protein in the precursor cells that give rise to neuroblastomas; consequently it is p73, rather than p53, that is inactivated in these tumours. Allelic loss at 1p36 has been reported in ...
bovine skeletal muscle cellsSkeletal muscle is an important component of animal body, and its growth and development directly affect the meat yield of livestock and poultry. As an important transcription regulator, fork head box protein O1 (Scientia Agricultura SinicaChao JIANGJiuPan ZHANGYaPing SONG...