aAs a result, a large portion of implanted cells undergo apoptosis and are cleared from the transplantation site by macrophages,which leads to incomplete repair 结果,被种入的细胞的一个大部分接受apoptosis和从移植站点被清除被巨噬细胞,导致残缺不全的修理 [translate] ...
A more precise system regulating GALNTL5 expression in the near future would elucidate the more exact function of it in spermiogenesis. Moreover, if it is possible to establish to specifically express GALNTL5 in cancer cells, GALNTL5 might serve as a novel anti-cancer drug. Materials and ...
If inactive neurons go into apoptosis to optimize the brain, is it then true that unused neurons which formed a memory once also go into apoptosis?Apoptosis:Apoptosis is the tendency of certain cells in the human body to unde...
cells. CASP4 expression is likely regulated in part by methylation status. Modulation of epigenetic mechanisms has been suggested as a potential strategy for the treatment of AD, especially with the success of this approach in some cancers [77,78,79]. Studies testing therapeutic DNA-methylating ...
Myotubes reactivated by CKI KD undergo apoptosis, which can be delayed by forced Bcl-2 expression.Deborah, PajalungaEleonora, M. R. PuggioniAlessia, MazzolaValentina, LevaAlessandra, MontecuccoMarco, Crescenzi
When cultured for 48h, lymphocytes treated with ECP underwent accelerated apoptosis (tested as annexin V binding cells and as intracellular histone-associated DNA fragments) in comparison with lymphocytes from the other samples. This enhanced programmed cell death could not be prevented by IL-2. ...
We previously showed that when the plasma membrane wound healing response is inhibited by chelating intracellular Ca2+, cells treated with PFN and GzmB are more likely to die by necrosis than by apoptosis.11 We suspected that a similar shift in the balance between apoptosis and necrosis would occ...
Normal adherent cells are strongly dependent on adhesion to extracellular matrix for cell proliferation and undergo apoptosis if they are detached from the substratum, in a process known as anoikis [30]. In contrast, tumor cells can survive and grow without adhesion to a substratum; this is a ...
Through these dual functions, cells can activate p62 and induce selective autophagy upon the accumulation of autophagic cargoes. We also propose that p62 mediates the crosstalk between the ubiquitin-proteasome system and autophagy through its binding Nt-Arg and other N-degrons....
Infected cells are "primed" to undergo apoptosis, but cell death is prevented or delayed by viral inhibition of p53 function. It is possible that this blockade in the apoptosis signal transduction pathway could be relieved, or bypassed, by an agent that modulates apoptosis downstream of p53. ...