Apoptosis as a conserved pathway Intrinsic and extrinsic pathways of apoptosis What is the difference between intrinsic and extrinsic pathway of apoptosis? There are at least two broad signaling pathways that lead to apoptosis: the intrinsic p...
但细胞凋亡通路有所不同,信号既可以来自胞外信号分子的触发,对应的过程称为外部信号通路(extrinsic signal pathway,见下图)。凋亡信号也可以直接来自胞内分子,包括氧化应激、细胞色素C、DNA损伤和内质网应激信号(ER stress),这些相关的过程称为内部信号通路(Intrinsic signal pathway,见下图标注)。这些凋亡信号很多也会...
参考文献 [1] Varfolomeev, Eugene E., and Avi Ashkenazi. "Tumor necrosis factor: an apoptosis JuNKie?." cell 116.4 (2004): 491-497. [2] Hongmei, Zhao. "Extrinsic and intrinsicsignal pathway review." Apoptosis and medicine. InTechOpen, 2012.[3] Xiong, Shunbin, et al. "Mitochondria-medi...
Aims. To clarify the role of extrinsic and intrinsic apoptosis pathways in human liver disease, we studied the mRNA expression of Fas/FasL, TNF-伪 and Bcl-2, Bax and Bad in biopsies from patients with different degrees of liver damage and determined whether HCV and HBV infection modulates ...
(e.g., BCL-2) BCL-2 family proteins. Cytochrome c binds to Apaf-1, which recruits procaspase-9, forming the apoptosome. In the apoptosome, caspase-9 is activated by autoproteolytic cleavage, initiating the caspase-processing cascade. The extrinsic pathway is activated by engagement of ...
intrinsic pathway extrinsic pathway p53 See all related content apoptosis, inbiology, a mechanism that allowscellsto self-destruct whenstimulatedby the appropriate trigger. Apoptosis can be triggered by mild cellular injury and by various factors internal or external to the cell; the damaged cells are...
Apoptosis is a tightly controlled pattern of programmed cell death characterized by distinct morphological changes along with the activation of specific caspases and mitochondrial control pathways. It can be triggered via intrinsic or extrinsic pathways. The intrinsic pathway can be activated by cell stres...
Apoptosis can be induced by the extrinsic or death receptor pathway and the intrinsic or mitochondrial pathway. The extrinsic pathway is initiated after an apoptotic ligand (e.g. FasL, TNF-α, TRAIL) binds to its death receptor. Subsequently, death-inducing signaling complex is formed resulting ...
The initiation of apoptosis is tightly regulated by activation mechanisms, because once apoptosis has begun, it inevitably leads to the death of the cell.The two best-understood activation mechanisms are the intrinsic pathway (also called th...
Apoptotic caspases are activated upon the receipt of either an extrinsic or an intrinsic death signal. The extrinsic pathway (green arrows) is initiated by ligand binding to cell surface death receptors (TNF RI, Fas/CD95, DR3, TRAIL R1/DR4, TRAIL R2/DR5) followed by receptor oligomerization...