The purpose of this study was to examine the association between the apolipoprotein E (APOE) ε4 allele and neurocognitive functioning following traumatic brain injury (TBI) in military service members and veterans (SMVs). Participants included 176 SMVs with a history of remote TBI (≥1 year ...
We also conducted another pooled analysis where we added a sex indicator variable and 5 additional covariates that were products of the sex variable with each APOE genotype variable to test for sex interactions. The age-dependent curves shown in Figure 1 were derived by adding several quadratic ...
Apolipoprotein E (apoE) is a 34 kDa glycoprotein involved in lipid metabolism. The humanAPOEgene encodes for three different apoE protein isoforms: E2, E3 and E4. The interest in apoE isoforms is high for epidemiological research, patient stratification and identification of those at increased r...
APOEApolipoprotein EDisease riskBiomarkersThe three main alleles of the gene (ε4, ε3 and ε2) carry differential risks for conditions including Alzheimer's disease (AD) and cardiovascular disease. Due to their clinical significance, we explored disease associations of the genotypes using a ...
BACKGROUND Apolipoprotein E genotype influences lipids and lipoproteins and, therefore, possibly the risk of IHD. METHODS We genotyped 9,241 white women and men from the general population and 940 white women and men with IHD. RESULTS Test of interaction suggested that APOE genotype may influence ...
apolipoprotein Egrey matter atrophyhomocysteinevitamin B 12Aims The aim of the present study was to investigate whether the effects of vitamin B12 and homocysteine on brain volume are influenced by apolipoprotein E ( APOE ) genotype. We examined the effects in each subgroup ( APOE 蔚4 carriers ...
The e4 allele has been associated with cerebral palsy (CP), and the e2 allele has been associated with worse neurological outcome with congenital heart dis- ease. This study was done to test the hypothesis that the APOE genotype is associated with outcome among neonates who survive after ...
Apolipoprotein E*4 (APOE*4) Genotype Is Associated with Altered Levels of Glutamate Signaling Proteins and Synaptic Coexpression Networks in the Prefrontal... Apolipoprotein E*4 (APOE*4)genotype is associated with altered levels of glutamate signaling proteins and synaptic coexpression networks in the...
摘要: apolipoprotein e4 (apoe4) genotype and/or gender do not appear to predict a response to donepezil in patients with mild-to-moderate alzheimer's disease-载脂蛋白E4(ApoE4的)基因型和/或性别没有出现预测患者轻度至中度阿尔茨海默氏病为多奈哌齐响应-知来论文发表中心...
INTRODUCTION: The apolipoprotein E ( APOE ) 4 allele associates with memory impairment in neurodegenerative diseases. Its association with memory after mild traumatic brain injury (mTBI) is unclear. METHODS: mTBI patients (Glasgow Coma Scale score 13-15, no neurosurgical intervention, extracranial Abbre...