Polymorphism in the apolipoprotein E (APOE) gene is a major genetic risk determinant of late-onset Alzheimer disease (AD), with the APOE*ε4 allele conferring an increased risk and the APOE*ε2 allele conferring a decreased risk relative to the common APOE*ε3 allele. Strong evidence from cl...
Polymorphism in the apolipoprotein E (APOE) gene is a major genetic risk determinant of late-onset Alzheimer disease (AD), with the APOE*ε4 allele conferring an increased risk and the APOE*ε2 allele conferring a decreased risk, relative to the common APOE*ε3 allele. Strong evidence from ...
Apolipoprotein E (APOE) polymorphisms influence Alzheimer's disease (AD) risk. APOE ε4 increases AD risk and is associated with changes to AD pathological hallmarks. APOE ε4 carriers show increased Aβ and tau pathologies, neuroinflammation, synaptic dysfunction, and mitochondria/metabolism disruptions...
Alzheimer’s disease (AD) is a complex, progressive primary neurodegenerative disease. Since pivotal genetic studies in 1993, the ε4 allele of the apolipoprotein E gene (APOE ε4) has remained the strongest single genome-wide associated risk variant in AD. Scientific advances inAPOEbiology, AD ...
The protein exists in 3 different isoforms coded for by alleles ε2, ε3 and ε4. Recent studies have shown that the frequency of the APOE ε4 allele is much greater among individuals with Alzheimer's disease than age-matched healthy controls [an approximate 4-fold increase (36.6 vs 9.4%...
The seeded growth of pathogenic protein aggregates underlies the pathogenesis of Alzheimer’s disease (AD), but how this pathological cascade is initiated is not fully understood. Sporadic AD is linked genetically to apolipoprotein E (APOE) and other genes expressed in microglia related to immune, ...
eAppendix. Data Set Descriptions eFigure 1. Forest Plots of the Log Odds Ratios of Developing Alzheimer Disease for Men and Women with the APOE ε3/ε4 Genotype from 22 Independent Studies from Ages 55 to 85 eFigure 2. Forest Plots of the Log Odds Ratios of Developing Mild Cognitive Impai...
Influence of the apolipoprotein E genotype on amyloid deposition and neurofibrillary tangle formation in Alzheimer's disease The effect of the apolipoprotein E genotype on the development of late onset Alzheimer's disease is still debated. Neuropathological studies of Alzheimer's... ZS Nagy,MM Esir...
APOE, which encodes apolipoprotein E, is the most prevalent and best established genetic risk factor for late-onset Alzheimer’s disease. Current understanding of Alzheimer’s disease pathophysiology posits an important role for apolipoprotein E in the disease cascade via its interplay with β-amyloid...
Recent studies have provided evidence of association of apolipoprotein E (ApoE) ε4 allele and late onset familial and sporadic Alzheimer's disease (AD). Epidemiological studies have established allelic variation at the ApoE locus. We have analyzed the ApoE gene polymorphism in a sample of 416 Ita...