Genetic variation in apolipoprotein E(APOE)influences Alzheimer's disease(AD)risk.APOEε4 alleles are the strongest genetic risk factor for late onset sporadic AD.The AD risk is dose dependent,as those carrying one APOEε4 allele have a 2-3-fold increased risk,while those carrying twoε4 ...
Polymorphism in the apolipoprotein E (APOE) gene is a major genetic risk determinant of late-onset Alzheimer disease (AD), with the APOE*ε4 allele conferring an increased risk and the APOE*ε2 allele conferring a decreased risk, relative to the common APOE*ε3 allele. Strong evidence from ...
Polymorphism in the apolipoprotein E (APOE) gene is a major genetic risk determinant of late-onset Alzheimer disease (AD), with the APOE*ε4 allele conferring an increased risk and the APOE*ε2 allele conferring a decreased risk relative to the common APOE*ε3 allele. Strong evidence from cl...
The protein exists in 3 different isoforms coded for by alleles ε2, ε3 and ε4. Recent studies have shown that the frequency of the APOE ε4 allele is much greater among individuals with Alzheimer's disease than age-matched healthy controls [an approximate 4-fold increase (36.6 vs 9.4%...
1997. Arteriosclerosis, apolipoprotein E, and Alzheimer's disease. Lancet. 349(9059):1174. :Kalaria R. N. (1997). Arteriosclerosis, apolipoprotein E, and Alzheimer’s disease . Lancet 349 , 1174 10.1016/S0140-6736(05)63052-8 [ Cross Ref ]Kalaria RN. Arteriosclerosis, apolipoprotein E, and...
Apolipoprotein E: structure, func- tion, and possible roles in Alzheimer's disease. Ann N Y Acad Sci 1996;777:139-45.Mahley RW, Nathan BP, Pitas RE. Apolipoprotein E: Structure, function, and possible roles in Alzheimer's disease. Ann N Y Acad Sci 1996;777:139-45....
Fig. 1: Hypothesized role of apolipoprotein E (APOE) and lymphatic vessels in Alzheimer disease (AD). Schematic depiction of mouse ApoE and human APOE isoforms (top right), with yellow indicating the presence of cysteine [C] and blue indicating the presence of arginine [R]. Illustration of ...
Scientists have discovered a previously unknown mechanism by which apolipoprotein E, a molecule whose mutation is linked to Alzheimer's disease (AD), stimulates degradation of sticky amyloid beta (A-beta) protein within the brain. The research, published
Recent studies have provided evidence of association of apolipoprotein E (ApoE) ε4 allele and late onset familial and sporadic Alzheimer's disease (AD). Epidemiological studies have established allelic variation at the ApoE locus. We have analyzed the ApoE gene polymorphism in a sample of 416 Ita...
Apolipoprotein E and Alzheimer's disease: molecular mechanisms and therapeutic opportunities.[see comment]. [Review] [100 refs] The effect of the apolipoprotein E genotype on the development of late onset Alzheimer's disease is still debated. Neuropathological studies of Alzheimer's... A Cedazo...