Polymorphism in the apolipoprotein E (APOE) gene is a major genetic risk determinant of late-onset Alzheimer disease (AD), with the APOE*ε4 allele conferring an increased risk and the APOE*ε2 allele conferring a decreased risk relative to the common APOE*ε3 allele. Strong evidence from cl...
Polymorphism in the apolipoprotein E (APOE) gene is a major genetic risk determinant of late-onset Alzheimer disease (AD), with the APOE*ε4 allele conferring an increased risk and the APOE*ε2 allele conferring a decreased risk, relative to the common APOE*ε3 allele. Strong evidence from ...
Apolipoprotein E (APOE) polymorphisms influence Alzheimer's disease (AD) risk. APOE ε4 increases AD risk and is associated with changes to AD pathological hallmarks. APOE ε4 carriers show increased Aβ and tau pathologies, neuroinflammation, synaptic dysfunction, and mitochondria/metabolism disruptions...
Corder, E. H. et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261, 921–923 (1993). CAS PubMed Google Scholar Mahley, R. W. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Sci...
The protein exists in 3 different isoforms coded for by alleles ε2, ε3 and ε4. Recent studies have shown that the frequency of the APOE ε4 allele is much greater among individuals with Alzheimer's disease than age-matched healthy controls [an approximate 4-fold increase (36.6 vs 9.4%...
The seeded growth of pathogenic protein aggregates underlies the pathogenesis of Alzheimer’s disease (AD), but how this pathological cascade is initiated is not fully understood. Sporadic AD is linked genetically to apolipoprotein E (APOE) and other genes expressed in microglia related to immune, ...
Influence of the apolipoprotein E genotype on amyloid deposition and neurofibrillary tangle formation in Alzheimer's disease The effect of the apolipoprotein E genotype on the development of late onset Alzheimer's disease is still debated. Neuropathological studies of Alzheimer's... ZS Nagy,MM Esir...
Genetic and transcriptomic studies in patients and cellular models are converging on a key role for lipids and the immune system. ADAPTED aimed to develop a comprehensive atlas of changes in metabolic and protein pathways in the blood and brain and determine whether these are driven by the ...
Immunol Rev. 2024 Oct; 327(1):43-52.IR Abstract Alzheimer's disease (AD) is a progressive neurological disorder and the most common cause of dementia. Genetic analyses identified apolipoprotein E (APOE) as the strongest genetic risk for late-onset AD. Studies...
longevity in people with Down syndrome resulting in an increased population that may be subjected to many of the same risk factors as those with Alzheimer's disease. It is well established that harboring one or both apolipoprotein E4 alleles greatly increases the risk for Alzheimer's disease. Ho...