Department of Pharmacology and Therapeutics, The University of Melbourne, Melbourne, Parkville, 3010, Victoria, Australia Shane Antony Liddelow Brigham and Women’s Hospital, Harvard Medical School, Boston, 02115, Massachusetts, USA Scott T. Smith, Caroline Baufeld & Oleg Butovsky Appel Alzheimer’s...
Australia; 4A collaboration between the University Medical Schools and National Health Service in Aberdeen, Dundee, Edinburgh and Glasgow, UK; 5Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK; 6Department of Psychology, ...
This project was supported by the Department of Veteran Affairs, NHMRC (Australia), the McCusker Foundation for Alzheimer's Disease Research, and US NIH Program AG10491. SM Laws is a recipient of a Dora Lush (Biomedical) postgraduate research scholarship from the NHMRC (Australia). Author info...
Genome-wide association analysis and CRISPR–Cas9 genome editing identified rs1921622, a genetic variant in an enhancer element of IL1RL1, which downregulates gene and protein levels of sST2. Mendelian randomization analysis using genetic variants, including rs1921622, demonstrated that decreased sST2 ...