APOE e4 genotypes increase risk of delirium during COVID-19-related hospitalizations: evidence from a large UK cohort. J Gerontol A. 2022;77(4):879–80. Article CAS Google Scholar Tavares-Júnior JWL, Oliveira DN, da Silva JBS, Feitosa WLQ, Sousa AVM, Cunha LCV, Gaspar SB, Gomes CMP...
doi:10.1016/J.JALZ.2019.06.2526Evelyn FokuohWang KeshengWileyAlzheimer's & Dementia
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The APOE4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD). The contribution of microglial APOE4 to AD pathogenesis is unknown, although APOE has the most enriched gene expression in neurodegenerative microglia (MGnD).
(Axol Bioscience, Cambridge, UK). And we use another line of human iPSC to do the similar experiment, which was from Accegen Biotechnology, USA. The PLO/Laminin-coated plates were used as the culture plate in the differentiation of NSCs into neurons. And then the cells were cultured in ...
All patients satisfied UK PD Society Brain Bank clinical diagnostic criteria for PD,14 met criteria recently proposed by a Movement Disorder Society Task Force for probable dementia associated with PD,15 and had onset of parkinsonism more than 1 year before the diagnosis of dementia. Data on 57 ...
Gene set enrichment analysis For all datasets, Wilcoxon rank-sum test was performed using the Presto R package. The receiver-operator area under the curve (AUC) was used to rank genes for downstream GSEA using the msigdbr R package and Hallmark and KEGG gene sets. GSEA was performed in R ...
单位:田金洲 杨承芝 袁致祥 北京中医药大学东直门医院 北京100700;Judy Haworth Sian MacGowan Gordon Wilcock French Hospital, University of Bristol, UK. 关键词:ApoEε4;阿尔茨海默氏病;分子遗传学;分子生物学 北京中医药大学学报990501 指导:Gordon Wilcock ...
88) to find gene sets in the KEGG database89 for mouse associated with Entrez gene IDs of the DE genes. P values are based on a hypergeometric test and are adjusted for multiple testing using the Benjamini–Hochberg method90. Significantly enriched gene sets were filtered to have an adjusted...
The ε4 allele of APOE gene (APOE4) is the strongest genetic risk factor for AD among the three polymorphic alleles (APOE2, APOE3, and APOE4)4,5. Apolipoprotein E (apoE) is produced primarily by astrocytes in the central nervous system as a carrier of cholesterol and other lipids to su...