Stunning advances in gene research and data mining will predict diseases and devise treatments tailored to each of us.
“Multi-omics is the only way forward,” says epidemiologist Cornelia van Duijn, at the University of Oxford, UK. “We can’t study the effect of one gene at a time, we need to look at the aggregate of genes; moreover, we need more than one ‘omic-wide’ dataset to not miss somet...
public health INTRODUCTION Background and purpose During the years prior to the turn of the century, scientific and medical attention for genetic disorders was mainly focused on under- standing rare single-gene disorders, such as Huntington's disease, Duchenne muscular dystrophy, and cystic fibrosis ...
Neuronal migration, the process by which neurons migrate from their place of origin to their final position in the brain, is a central process for normal brain development and function. Advances in experimental techniques have revealed much about many of
but they may be the exceptions and not the rule. The reasons for this run from simple issues such as lack of conservation, to more complicated situations where gene duplications or redundancy may prevent a one-to-one recapitulation, to a lack of shared physiology or anatomy, which may or ma...
SH-SY5Y cells are the most used cell line for studying AD. Isolated from a human neuroblastoma, they are cultured in 2D and 3D systems [3,5]. AD hallmarks are induced in different manners, either with the overexpression of the APP gene [113,122] or with the exposure to Aβ molecules ...
The high number of DNA-vaccines tested in clinical trials emphasizes their important role for future medical approaches. This review aims to summarize current achievements and ongoing developments in the design of optimized DNA vaccines and delivery methods. 2. Course of Action of DNA Vaccines The ...
themselves for change; (4) action—changed but the risk is still high that they will return to their old behaviour; (5) maintenance—behaviour has started to become a habit; and (6) termination—a new behaviour is established and it is not likely they will return to their old behaviour....