Background & Aim The apolipoprotein E4 (ApoE4) is the most prevalent genetic risk factor for sporadic Alzheimer's disease (AD). More than 50% of AD patients express the ApoE4 protein; which increases the risk of prevalence for AD since it lowers the age of onset by as much as 10-20...
《自然》新闻:This is how an Alzheimer’s gene ravages the brain 链接 《自然》论文: APOE4 impairs myelination via cholesterol dysregulation 发布于 2022-11-30 10:54・IP 属地上海 写下你的评论... 登录知乎,您可以享受以下权益: 更懂你的优质内容 ...
There are dozens of genes that have been linked to increased Alzheimer’s risk. Some of these genes have just a tiny bit of influence over a person’s likelihood of developing Alzheimer’s; others have quite a lot. One particular gene variant, called APOE4, has accrued a reputation as “...
The results were quite remarkable. Children and adolescents who carried the APOE4 allele, the so-called “Alzheimer’s gene,” showed measurably lower scores on verbal, performance and full-scale IQ assessments in comparison to those not positive for this genetic marker. ...
Clinical Benefits of Tramiprosate in Alzheimer's Disease Are Associated with Higher Number of APOE4 Alleles: The "APOE4 Gene-Dose Effect 阿尔兹海默病中曲米普酸的临床疗效与APOE4等位基因数目增加有关:“APOE4基因剂量效应” 相关领域 等位基因 疾病 阿尔茨海默病 遗传学 基因 医学 生物 内科学 ...
Further studies to clarify this interaction may improve our understanding of the generic risks for AD. Copyright © 2005 S. Karger AG, Basel 展开 关键词: Alzheimer disease Apolipoprotein E Estrogen Estrogen-metabolizing gene polymorphism DOI: 10.1159/000082663 被引量: 45 年份: 2005 ...
The ε4 allele of theapolipoprotein Egene (APOE) is the strongest genetic risk factor for late-onset (> 65 years) Alzheimer’s disease (AD) [1,2,3]. Inheritance of one copy of this allele increases late-onset AD risk by two to fourfold, with two copies conferring an eight to tw...
Apolipoprotein-E4 (ApoE4) is an important genetic risk factor for Alzheimer’s disease. The development of targeted-replacement human ApoE knock-in mice facilitates research into mechanisms by which ApoE4 affects the brain. We performed meta-analyses and meta-regression analyses to examine differences...
Alzheimer's & Dementia Volume 4, Issue 4, Supplement, July 2008, Page T598Abstract Poster presentation: Tuesday posterP3-259: GAB2 gene does not modify Alzheimer's risk in Spanish APOE E4 carriers Author links open overlay panelAgustín Ruíz * 1, Mercè Boada 2, Reposo Ramirez-Lorca 1, ...
APOE ε4 is the strongest genetic risk factor for late-onset Alzheimer's disease (AD) and accounts for 50-65% of late-onset AD. Late-onset AD patients carrying or not carrying APOE ε4 manifest many clinico-pathological distinctions. Thus, we applied a weighted gene co-expression network an...