-TR小鼠;且与3月龄APOE3-TR小鼠相比,10月龄APOE3-TR小鼠内嗅皮层,新大脑皮层,海马及小脑区明显升高.而雄性组,IgG含量在年龄和基因型中均无明显统计学差异.双染共定位发现,IgG免疫阳性细胞主要为小胶质细胞和少量丘脑背侧内核处神经元.APOE-TR小鼠皮层内均见散在分布的少量Aβ阳性染色,尤以10月龄APOE4-TR...
but not in their apoE4-TR counterparts [2,19]. In this study, we focused on the sex differences in cognitive, depressive, and anxiety- phenotypes and effects of metformin therapy in the aged apoE-TR mice.
The two mouse lines did not differ in a non-spatial visible-platform version of the task. This hAPP-Yac/apoE-TR model may thus provide a useful tool to study the mechanisms involved in the antagonistic pleiotropic effects of APOE-4 on cognitive functions. 展开 ...
All ApoE-TR mice exposed to CUMS at 3 months old recovered from a depression-like state by the age of 12 months. Of note, ApoE4-TR mice, unlike age-matched ApoE3-TR mice, displayed impaired spatial cognitive abilities, loss of GABAergic neurons, decreased expression of Reelin, PSD95, SY...
All ApoE-TR mice exposed to CUMS at 3 months old recovered from a depression-like state by the age of 12 months. Of note, ApoE4-TR mice, unlike age-matched ApoE3-TR mice, displayed impaired spatial cognitive abilities, loss of GABAergic neurons, decreased expression of Reelin, PSD95, ...
ApoE~(-/-)小鼠 例句>> 补充资料:L(+)-鼠李糖一水合物 鼠李糖,一水 CAS:10030-85-0分子式:C6H14O6分子质量:182.17熔点:91-93℃中文名称:L(+)-鼠李糖一水合物 鼠李糖,一水英文名称:L(+)-Rhamnose monohydrate; Rhamnose,monohydrate iso-Ducitol用途:用作生化试剂。 说明:补充资料仅用于学习参考,请勿用于...
Clinical Benefits of Tramiprosate in Alzheimer's Disease Are Associated with Higher Number of APOE4 Alleles: The "APOE4 Gene-Dose Effect 阿尔兹海默病中曲米普酸的临床疗效与APOE4等位基因数目增加有关:“APOE4基因剂量效应” 相关领域 等位基因 疾病 阿尔茨海默病 遗传学 基因 医学 生物 内科学 ...
2023东北心血管病论坛(NCF)期间,山东大学齐鲁医院张运院士结合REDUCE-IT试验、STRENGTH试验以及PROMINENT试验等近年来血脂领域中备受关注的热点研究结果,以独到视角剖析抗动脉粥样硬化的新靶标——富含甘油三酯的脂蛋白(TRLs),并对未来我国患者降脂治疗的真正核心进行了深入解读。
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