Utilizing female APOE㏕R mice maintained on a high‐fat diet background we induced ovarian failure through repeated VCD injections, to mimic human menopause. At 12 months of age, recognition memory and spatial memory were assessed using object recognition, Y﹎aze spontaneous alternation, and Barnes...
The APOE-4 allele is associated with increased cognitive decline during normal aging and Alzheimer's disease. However, several studies intriguingly found a beneficial effect on cognition in young adult human APOE-4 carriers. Here, we show that 3-month old bigenic hAPP-Yac/apoE4-TR mice outperfo...
All ApoE-TR mice exposed to CUMS at 3 months old recovered from a depression-like state by the age of 12 months. Of note, ApoE4-TR mice, unlike age-matched ApoE3-TR mice, displayed impaired spatial cognitive abilities, loss of GABAergic neurons, decreased expression of Reelin, PSD95, SY...
All ApoE-TR mice exposed to CUMS at 3 months old recovered from a depression-like state by the age of 12 months. Of note, ApoE4-TR mice, unlike age-matched ApoE3-TR mice, displayed impaired spatial cognitive abilities, loss of GABAergic neurons, decreased expression of Reelin, PSD95, ...
All ApoE-TR mice exposed to CUMS at 3 months old recovered from a depression-like state by the age of 12 months. Of note, ApoE4-TR mice, unlike age-matched ApoE3-TR mice, displayed impaired spatial cognitive abilities, loss of GABAergic neurons, decreased expression of Reelin, PSD95, ...
Methods: ApoE3-TR and apoE4-TR mice of both sexes were randomly assigned to the normal saline and metformin groups from 13 months to 18 months of age. Behavior tests (MWM, EPM, OFT, TST, FST) were conducted to assess cognition, anxiety, and depression-like behaviors. The mice's blood...
Estradiol enhances long term poten- tiation in hippocampal slices from aged apoE4-TR mice. Hippocampus 2007;17(12):1153-7.Yun SH, Park KA, Kwon S, Woolley CS, Sullivan PM, Pasternak JF, Trommer BL. Estradiol enhances long term potentiation in hippocampal slices from aged apoE4-TR mice. ...
1) HO-APOE-TR mice HO-APOE-TR小鼠2) apoE-/-/LDLR-/-mice apoE-/-/LDLR-/-小鼠3) ApoE~(-/-) mice ApoE-/-小鼠 1. The results indicate that the spots have been detected in arota arch,arota branch and abdorminal arota of ApoE~(-/-) mice(eight-week-old knock-out mice). ...
Ovariectomy increases sEPSC frequency in female apoE4 TR mice.doi:10.1371/JOURNAL.PONE.0094071.G004C. RebeccaS. ShylaRisher M-LouiseK. ShawnL. RebekahG. HannahH. ScottSwartzwelderD. ScottPLOS ONE
doi:10.1016/j.jalz.2017.06.143Johansson, Jan O.Boehm-Cagan, AnatBielicki, John K.Michaelson, Daniel M.Alzheimers & Dementia