The maintenance of genomic integrity in the face of this potential off-target activity must require high fidelity DNA repair and strict regulation of APOBEC3 gene expression and enzyme activity. Conversely, the ability of specific members of the APOBEC3 family to activate DNA damage signaling ...
Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012] 基因名: APOBEC3B 别名: A3B,ARP4,ARCD3,PHRBNL,APOBEC1L,bK150C2.2,DJ742C19.2 基因ID: 9582 Chromosome:(GRCh37) 22 Start: 39378352 End: 39388784 Strand: 信号通路: APOBEC3B...
基因信息 基因名 Apobec3 基因曾用名 Arp3; Rfv3; Cem15; Apobec; Gm20117; BC003314 NCBI ID 80287 MGI ID 1933111 Ensembl ID ENSMUSG00000009585 Pubmed Apobec3 人类同源基因 APOBEC3 品系描述 These mice carry loxP sites flanking exon 3-4 of Apobec3 gene. When crossed with a Cre recombinase-expre...
Apobec3 基因曾用名 Arp3, Rfv3, Cem15, Apobec, Gm20117, BC003314 NCBI ID 80287 MGI ID 1933111 Ensembl ID ENSMUSG00000009585 Pubmed Apobec3 人类同源基因 APOBEC3H 品系描述 exon 3-4 of Apobec3 gene was deleted to generate Apobec3 knockout mice. ...
2012. An ancient history of gene duplications, fusions and losses in the evolution of APOBEC3 mutators in mammals. BMC Evol. Biol. 12:71. doi:10.1186/1471-2148-12-71.Munk, C.; Willemsen, A.; Bravo, I.G. An ancient history of gene duplications, fusions and losses in the evolution of...
Gene Symbol APOBEC3C Gene ID (NCBI) 27350 RRID AB_2057393 Conjugate Unconjugated Form Liquid Purification Method Antigen affinity purification UNIPROT ID Q9NRW3 Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Storage Conditions Store at -20°C. Stable for one year after ...
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA...
NF-κB signaling may also increase APOBEC3 expression indirectly via the transcription of pro-inflammatory mediators. For example, the NF-κB target geneIL-6has been shown to induceAPOBEC3Bexpression in hepatocellular carcinoma via JAK/STAT signaling [85,86]. Similarly, TNF-α has been found to...
which results in the complete loss of the coding part of theAPOBEC3Bgene and abolishesAPOBEC3Bgene expression; this deletion polymorphism produces a fusion product of theAPOBEC3Agene with the 3′-UTR ofAPOBEC3Bgene, and it has been associated with an increased risk of several types of cancer...