Gene ID (NCBI)10930 RRIDAB_10697687 偶联类型Unconjugated 形式Liquid 纯化方式Antigen affinity purification UNIPROT IDQ9Y235 储存缓冲液PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 储存条件Store at -20°C. Stable for one year after shipment.Aliquoting is unnecessary for -20oC storage. ...
Gene SymbolAPOBEC2 Gene ID (NCBI)10930 RRIDAB_10697687 ConjugateUnconjugated FormLiquid Purification MethodAntigen affinity purification Storage BufferPBS with 0.02% sodium azide and 50% glycerol pH 7.3. Storage ConditionsStore at -20°C. Stable for one year after shipment.Aliquoting is unnecessary for...
May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. Tissue Specificity: Expressed exclusively in heart and skeletal muscle. Sequence Similarities: Belongs to the cytidine and deoxycytidylate deaminase family. Database Links: Entrez Gene: ...
mRNA/protein expressionReal-time PCRWestern blottingIn this study, we evaluated APOBEC2 mRNA abundance and protein expression and the results indicated that APOBEC2 mRNA was most abundant in skeletal and cardiac muscle.Immunoreactive APOBEC2 was localized to the cell nucleus of developing myocardium ...
Compared with mice with an apobec-1+/+ background, CETP expression in apobec-1-/- mice caused a doubling of the plasma apoB-100 concentration (from 3.5+/-0.6 to 8.8+/-1.9 mg/dL, P<.01) and a much greater shift of plasma cholesterol from HDL to IDL/LDL as assayed by fast ...
For the pathogenic retrovirus human immunodeficiency virus 1 (HIV-1), there are widely expressed restriction factors, such as APOBEC3 proteins, tetherin/BST2, SAMHD1 and MX2, as well as TRIM5α. We previously found that the TRIM5α gene clearly affects SIVmac or HIV-2 replication, but the...
In 1987, two groups identified that tissue-specific expression of ApoB100 and ApoB48 from the ApoB gene depended on post-transcriptional modifications of messenger RNA rather than differences in their genomic content (Chen et al., 1987; Powell et al., 1987). In both human and rat enterocyte...
The experiments described in this work were designed with the goal of learning about the events accompanying retina and optic nerve regeneration and about the biochemical function of Apobec2 proteins, simultaneously. Herewith, the following is characterized during regeneration: gene expression programs, ...
Fig. 1. SIVmac and HIV-2 Vif counteract the antiviral activity of A3B. (a, c) 293T cells were transfected with expression plasmids for (a) SIVmacΔvif-Luc or SIVmac-Luc (c) HIV-2Δvif-Luc or HIV-2Δvif-Luc + HIV-2 Vif together with expression plasmids for rhA3A, hA3A, hA...
The promoter region of the HIV-LTR was PCR-amplified from pNLPFB (44) and subcloned as previously described to obtain the construct pLTR-Luc. A Tat expression vector (pTat) was constructed as previously described (43). A mutant lacking the vif gene in pNLPFB was obtained using point mutag...