Aplastic anemia is an acquired or constitutional trilineage bone marrow failure with peripheral pancytopenia, evidence of cellular hypoplasia of marrow, and replacement of normal cellular elements by fat. In some cases the marrow may be hypoplastic and the peripheral cytopenia relatively mild. The ...
The meaning of APLASTIC ANEMIA is anemia that is characterized by defective function of the blood-forming organs (such as the bone marrow) and is caused by toxic agents (such as chemicals or X-rays) or is idiopathic in origin.
Aplastic Anemia Aplastic anemiais characterized bypancytopeniaon peripheral smear. The criteria for severeaplastic anemiaincludes a bone marrow biopsy showing <50% normal cellularity in which fewer than 30% of the cells are hematopoietic and at least two of the following are present: absolute reticuloc...
Over time, the slowly proliferating clone (PNH, MDS) could become dominant. In some patients, stem cell injury may result in the simultaneous appearance of both autoimmune marrow suppression and clonality (PNH/AA overlap or hypoplastic MDS). Aerolysin-based assays should be useful in determining ...
All patients were studied to rule out infections, hypoplastic myelodysplasia/leukemia, paroxysmal nocturnal hemoglobinuria (PNH), and congenital marrow failure syndromes, including Fanconi anemia, dyskeratosis congenita, thrombocytopenia absent radius syndrome, Diamond-Blackfan anemia, Shwachman-Diamond syndrome,...
Myelodysplastic syndromes, aplastic anemia and hypoplastic leukemia: a comparative study on pathophysiology and treatmentTomonaga, M.Amenomori, T.Nagai, K.Kohno, T.EXCERPTA MEDICA INTERNATIONAL CONGRESS SERIES
Repopulation of Transplanted Bone Marrow in Patients with Aplastic and Hypoplastic AnemiasCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording,...
Hypoplastic myelodysplastic syndromeT lymphocyte subsetsLarge granular lymphocyteB lymphocyteFlow cytometryAims This study aims to compare the proportion of peripheral blood T lymphocyte subsets and related blood cell and bone marrow cytology indexes between patients with aplastic anemia (AA) and hypoplastic ...
Repopulation of Transplanted Bone Marrow in Patients with Aplastic and Hypoplastic Anemiasdoi:10.1159/000427442N. A. Lanzova
The diagnosis of aplastic anaemia is based on the presence of peripheral pancytopenia and a hypoplastic marrow without evidence of malignancy [9,12]. Examination of a blood film is mandatory, although care must be taken as concomitant drug administration (e.g., G-CSF or Epo) may cause mislead...