APEX2 PL revealed nuclear proteins that were previously not identified by conventional techniques. One of these, the Yer156C protein, is highly conserved but of unknown function. Its human orthologue, MYG1, is linked to developmental processes and dermatological diseases. A first characterization of...
To overcome the limitations of traditional methods, proximity labeling techniques like APEX2 have been developed. Unlike proximity-dependent biotin identification (BioID), which requires extended labeling times [14,15], or the antibody-dependent SPLAAT and EMARS methods [16,17], APEX2 enables rapid...