Waves of ubiquitin-dependent degradation of key cellular regulators are required to help drive the cell cycle through its various phases. In Nature, two complementary papers by Bashir et al.et al.CDH1) is also required in late G1 phase to control the activity of its fellow ubiquitin-ligase ...
2023年3月15日，来自美国丹娜—法伯癌症研究所的Edward T. Chouchani团队在Nature杂志上发表了一篇题为 Lactate regulates cell cycle by remodeling the anaphase promoting complex 的文章，他们确定了整个人类蛋白组的乳酸依赖性调节，证明了积累的乳酸通过对SUMO蛋白酶SENP1的直接抑制来重塑后期促进复合物（APC/C）以...
2023年3月15日,来自美国丹娜—法伯癌症研究所的Edward T. Chouchani团队在Nature杂志上发表了一篇题为Lactate regulates cell cycle by remodeling the anaphase promoting complex的文章,他们确定了整个人类蛋白组的乳酸依赖性调节,证明了积累的乳酸通过对SUMO蛋白酶SENP1的直接抑制来重塑后期促进复合物(APC/C)以调控细...
Nature | 乳酸通过重塑APC/C以调控细胞周期 快速分裂的细胞中往往含有高水平乳酸,这种称为有氧糖酵解的代谢现象与癌细胞的增殖有关,但积累的乳酸是否可以直接调节增殖过程尚不清楚。 2023年3月15日,来自美国丹娜—法伯癌症研究所的Edward T. Chouchani团队在Nature杂志上发表了一篇题为Lactate regulates cell cycle ...
后期促进复合物/细胞周期体(anaphase-promoting complex/cyclosome,APC/C) 是一种进化保守的泛素连接酶复合物，已经被证实是这一过程的关键参与者之一。APC / C复合体通过其亚基激活子（例如CELL CYCLE SWITCH 52 A2，CCS52A2）的辅助识别靶标蛋白，从而泛素化标记细胞周期蛋白调节其降解。研究发现缺失CCS52A2的...
This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011]. ...
Accumulation of nucleotide building blocks prior to and during S phase facilitates DNA duplication. Herein, we find that the anaphase-promoting complex/cyclosome (APC/C) synchronizes ribose-5-phosphate levels and DNA synthesis during the cell cycle. In l
APC7 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle...
Progression through the cell cycle requires the activity of two ubiquitination complexes, the Skp1—cullin—F-box-protein complex (SCF) and the anaphase-promoting complex/cyclosome (APC). Observations in the past year have revealed unexpected similarities between the \{SCF\} and the \{APC\} and...
Metabolic activities are often accompanied by cell cycle progression, yet known connections between these two processes remain limited. Here, we identified the isocitrate dehydrogenase 3β (IDH3β) as a novel substrate of anaphase-promoting complex/cyclosome (APC/C)-CDH1 and an important regulator of...