Ap−1及びnfat活性化阻害剤doi:WO2003103647 A1Susumu Muto武藤 進Akiko Itai板井 昭子WO2003103647A1 2003年6月5日 2003年12月18日 Inst Med Molecular Design Inc Inhibitors against the activation of ap-1 and nfat
此外,jun与fos家族成员还能与其它的转录因子家族如CREB/ATF, NFAT, ETS, NF-κB及细胞核激素受体结合而发挥作用。值得指出,不同的AP-1二聚体的活性呈现差异,例如fos/junD二聚体与靶基因启动子上AP-1结合位点的结合力明显高于fos/junB二聚体,这可能影响靶基因的转录速率,导致不同的生物学效应。 二、AP-1的...
Ets-1 has been found to physically interact with several nuclear proteins, including NFAT, AP1, and STAT5 =-=(23, 42, 43)-=-, which can modulate the activity of Ets-1. The physical interaction between Ets-1 and T-bet may be too weak to be detected by coimmunoprecipitation. We would...
此外,jun与fos家族成员还能与其它的转录因子家族如CREB/ATF,NFAT,ETS,NF-κB及细胞核激素受体结合而发挥作用。值得指出,不同的AP-1二聚体的活性呈现差异,例如fos/junD二聚体与靶基因启动子上AP-1结合位点的结合力明显高于fos/junB二聚体,这可能影响靶基因的转录速率,导致不同的生物学效应。
The data from luciferase assays indicate that K15 expression in BJAB cells induced NFAT and AP1 activities. The tyrosine residue in the C-terminal end of K15 required for the Lyn interaction appeared to be essential for NFAT/AP1 activation, highlighting the significance of the C-terminal SH2B ...
Myocyte enhancer factor 2 mediates calcium-dependent transcription of the interleukin-2 gene in T lymphocytes: a calcium signaling module that is distinct from but collaborates with the nuclear factor of activated T cells (NFAT). J Biol Chem 2004; 279: 14477–14480. Article CAS PubMed Google ...
BF2382pGL4.30[luc2P/NFAT-RE/Hygro]"质粒(空载体)/质粒(载体)" BF2383pGL4.30[luc2P/NFAT-RE/Hygro]"质粒(空载体)/质粒(载体)" BF2384pCL-Ampho"质粒(空载体)/质粒(载体)" BF2385pCL-Ampho"质粒(空载体)/质粒(载体)" BF2386pCDH-CMV-MCS-EF1-Puro"质粒(空载体)/质粒(载体)" ...
Also cells engineered to inhibit expression and/or function of NFAT/AP-1 pathway are provided. Disclosed cells are T and NK cells. It can be expanded to create homogeneous or heterogenous cell populations and/or combined with pharmaceutically acceptable carriers. It can be CAR cells. Methods to...
WB analysis of CF and NE of WASP-/- and WT cells showed the same level of NFATp in CF, but a markedly reduced level in the NE of WASP-/- cells This study suggests that NFAT nuclear translocation and AP-1 induction following TCR/CD28 ligation are impaired in WASP-/- T-cells. This...
此外,jim与fos家族成员还能与其它的转录因子家族 如CREB/ATF,NFAT,ETS,NF- kB及细胞核激素受体结合而发挥作用。值得指出,不同的AP-1二聚体的活性呈现差异,例如fos/junD二聚体与靶基因启动子上AP-1结合位点的结合力明显高于fos/jimB二聚体,这可能影响靶基因的转录速率,导 致不同的生物学效应。