AP1andMAPK激活子蛋白-1(activator protein 1, AP-1)由c-jun蛋白和c-fos蛋白家族成员组成,是细胞内归属于bZIP类DNA结合蛋白的一种重要的转录因子。c-jun蛋白家族和c-fos蛋白家族成员之间相互作用而形成多种形式的同源二聚体或异源二聚体AP- 1,存在于多种细胞中,可被激素、生长因子、细胞因子、神经介质、热...
1的活性除了经MAPK信号转导通路的磷酸化调控外, 其它一些蛋白激酶如PKC 和蛋白酪氨酸激酶亦可以调节活化AP-1。（一）c-fos的激活 c-fos基因启动子区主要由3个转录调控组件--cAMP反应组件(cAMP response element, CRE)、血清反应组件 (serum response element, SRE)及sis诱导组件 (sis inducible element, SIE)所...
AP-1的活性除了经MAPK信号转导通路的磷酸化调控外,其它一些蛋白激酶如PKC和蛋白酪氨酸激酶亦可以调节活化AP-1。 (一)c-fos的激活 c-fos基因启动子区主要由3个转录调控组件--cAMP反应组件(cAMPresponseelement,CRE)、血清反应组件(serumresponseelement,SRE)及sis诱导组件(sisinducibleelement,SIE)所组成。因此,c-fo...
Our studies establish FRA1 as a part of the molecular machinery controlling sensitivity to MAPK cascade inhibition allowing the development of mechanism-based therapies.doi:10.1007/s00018-022-04638-ySchneeweis ChristianDiersch SandraHassan Zonera
Ran GTPase activating protein 1 (RanGAP1) has been implicated in various diseases, but its role in colorectal cancer (CRC) progression remains unclear. Using tumor tissues and public databases, we found that RanGAP1 was significantly upregulated in CRC t
AP- 1的活性除了经MAPK信号转导通路的磷酸化调控外,其它一些蛋口激酶如PKC和蛋白酪氨酸激酶亦可以调节活化AP-1o (一 )c・fos的激活 c-fos基因启动子区主要山3个转录调控组件—CAMP反应组件(cAMP response element, CRE)、血清反应组件(serumresponse element, ...
(完整word版)AP1andMAPK激活子蛋白—1(activator protein 1, AP-1)由c—jun蛋白和c—fos蛋白家族成员组成,是细胞内归属于bZIP类DNA结合蛋白的一种重要的转录因子。c-jun蛋白家族和c-fos蛋白家族成员之间相互作用而形成多种形式的同源二聚体或异源二聚体AP- 1,存在于多种细胞中,可被激素、生长因子、细胞因子...
Authors - Yan Gong View Article human WB,IHC,IP Cancer Gene Ther METTL3-mediated RanGAP1 promotes colorectal cancer progression through the MAPK pathway by recruiting YTHDF1 Authors - Rui Yang KD Validated View ArticleProteintech North America (HQ) Proteintech Group, Inc 5500 Pearl Street, Suite...
The stress-activated protein kinase/c-jun N-terminal kinase (SAPK/JNK) family of proteins includes mitogen-activated protein kinases (MAPKs) that are activated by stress, inflammatory cytokines, mitogens, oncogenes, and inducers of cell differentiation and morphogenesis. Upon activation of the SAPK...
Scaffold proteins of mammalian MAPK cascades enable the efficient activation of specific MAPK pathways by increasing the local concentration of signaling components.35,36 In this study, however, elevated JNK was found in Jsap1:Jlp dKO neurons and mice (Figure 7). As described below, ablating the...