(ras 鸟甘酸交换因子 GEF) →ras 蛋白 →Raf (MAPK EGFR 表达 临床病理特征 n ) ( ) kinase kinase →MEK MAPK kinase →MAPK,通过 ( ) 阴性 弱阳性 阳性 阳性率 % 分化程度 cjun 、cfos 将信号传导至核内激活 AP1 ; ②PI3K 通路 :erbB 配体 ———erbB受体 →PI3K →PI (3 ,4 ,5) 高、中...
EGF treatment reduced pYAP and increased TAZ levels, as well as CTGF, CYR61, AMOTL2 mRNA and CTGF and CYR61 protein expression, concomitant with the activation of canonical EGFR-downstream pathways including MAPK and PI3K-AKT-mTOR, reflected by increased phosphorylation of ERK1/2, AKT, and ...
Reagents were obtained from the following sources: antibodies against phospho-Y1068 EGFR (2234S), EGFR (4267 L), TSC2 (4308S), Rheb (13879S), mTOR (2983S), phospho-T389 S6K1 (9234S), S6K1 (9202S), phospho-S473 AKT (4060S), phospho-Thr202/Tyr204-p44/42 MAPK (Erk1/2) (...
E2 induced apoptosis and increased phosphorylation of c-jun for ER + MCF7 cells but not in MDA-MB 231 ER − cells (Altiok et al.2007). Cellular survival might be also mediated by activation of the MAPK and PI3K/
This is accompanied by down-regulation of Akt and activation of caspase-3 and p38 mitogen-activated protein kinase (MAPK). Surprisingly, removal of TGFalpha (using the null strain) does not ameliorate the LMP1-induced phenotype, but instead accelerates the deterioration. Consistent with this, EGFR...
[0058]图5表示汉黄芩素可减弱三阴性乳腺癌细胞中EGF信号对细胞生长刺激效应;(5A,5B)表示免疫印迹法分析三阴性乳腺癌细胞中MAPK/ERK磷酸化, 其中三阴性乳腺癌细胞用10ng/ml EGF单独处理或与标示浓度的汉黄芩素共同处理过。(5C, 5D)表示免疫印迹法分析三阴性乳腺癌细胞中cyclin D1蛋白表达, 其中三阴性乳腺癌细胞...
(EGF), leads to phosphorylation and dimerization of the receptor, recruitment of proteins containing Src homology 2 (SH2), and phosphotyrosine-binding (PTB) domains, and activation of multiple downstream signaling pathways, including the mitogen-activated protein kinase (MAPK) pathway, the ...
Adaptive and acquired resistance to EGFR inhibitors converge on the MAPK pathway. Theranostics. 2016;6:1232–43. Article CAS PubMed PubMed Central Google Scholar Pattabiraman DR, Weinberg RA. Tackling the cancer stem cells—what challenges do they pose? Nat Rev Drug Discov. 2014;13:497–512...
The NPRA/PGRMC1/EGFR complex further activated the MAPK/ERK signaling pathway and induced transcription factor AP1 expression and activation, which facilitated proliferation and inhibited apoptosis of KGN cells (Figure 8). These findings demonstrate that ANP improves ovarian functions via the NPRA/PGR...
Precision drugging of the MAPK pathway in head and neck cancer Article Open access 16 March 2022 The influence of PI3K inhibition on the radiotherapy response of head and neck cancer cells Article Open access 01 October 2020 Introduction Head and neck cancers rank as the sixth most common ...