银屑病是一种多因素的慢性炎症性皮肤病,其发病机制取决于易感基因突变和环境触发因素。其发病机制为从应激角质形成细胞释放的自RNA / DNA刺激浆细胞样DCs(pDC)和皮肤DC中的细胞内TLR,以启动Th17细胞依赖性免疫反应。c-Jun和JunB在...
Interleukin (IL)-17-producing T helper (Th17) cells are crucial for host defense against extracellular microbes and pathogenesis of autoimmune diseases. Here we show that the AP-1 transcription factor JunB is required for Th17 cell development.Junb-deficient CD4+T cells are able to developin ...
MicroRNA-181c promotes Th17 cell differentiation and mediates experimental autoimmune encephalomyelitis. Authors - Zimu Zhang View Article human WB Nat Cell Biol An ARF6-Exportin-5 axis delivers pre-miRNA cargo to tumour microvesicles. Authors - James W Clancy View Article human WB Nat Commun K235...
TH17/ILC3 gene expression in ALCL and link to the deregulated BATF/BATF3/AP-1 activity.amRNA expression of TH17/ILC3-associated genes and, as control,GAPDHwere analyzed by RT-PCR.bMore global approaches to TH17/ILC3 gene expression in ALCL. Upper panels, GSEA of differentially expressed ge...
It is a negative regulator of the CARMA1 signalosome and suppressor of Th1-and Th17-mediated inflammatory responses. 实验方案 Product Specific Protocols WB protocol for RAIDD antibody 10401-1-AP Download protocol IHC protocol for RAIDD antibody 10401-1-AP Download protocol IP protocol for RAIDD ...
AP-1-IRF composite element (AICE)5′-TGAC/GTCANNNNGAAA-3′IRF8 cooperation with BATF3-JUN/AP-1 family proteins on the AICE is required for DC, B cell and Th17 differentiation.[27,118] Zinc finger-IRF composite element (ZICE)5′-GGGAAANNGAAA-3′Ikaros is essential for IRF4 binding...
BATF/BATF3 are important for expression of genes in ALK+ ALCL that are associated with the TH17/group 3 innate lymphoid cell gene signature observed in this lymphoma [85]. Likewise, BATF3 expression is important for both the expression and repression of genes that characterize cHL [122]. ...
Role of Th17 cells in the pathogenesis of CNS inflammatory demyelination 2013, Journal of the Neurological Sciences Show abstract Colony stimulating factors and myeloid cell biology in health and disease 2013, Trends in Immunology Show abstract The granulocyte-macrophage colony-stimulating factor receptor:...
Pathogenic Th17 cell-mediated liver fibrosis contributes to resistance to PD-L1 antibody immunotherapy in hepatocellular carcinoma Authors - Meiying Song View Article human,mouse IHC J Cell Mol Med Ozone therapy promotes the differentiation of basal keratinocytes via increasing Tp63-mediated transcription ...
The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells. Authors - Jing Geng View Article Mol Cell PMID: 28366643 Authors - Sophie Barral View Article human WB Nat Commun Requirement for p62 acetylation in the aggregation of ubiquitylated proteins under nutri...