Th17诱导分化实验检测Fra2对T细胞的生物学行为的影响,以阐明Fra2在银屑病中发病机制中的作用.结果构建的银屑病小鼠模型的表型与临床银屑病人表型类似;mRNA测序分析提示其OX40+细胞固有性免疫和适应性免疫失调;CBA和phosflow检测发现了P38磷酸化水平下调;流式和Cy TOF检测发现以活化的Th1和Th17为主的免疫表型;Th17诱导...
目的:探讨补中益气汤通过微小RNA-155(miR-155)/Nedd4家族相互作用蛋白1(Ndfip1)/磷酸酯酶与张力蛋白同源物(Pten)轴调控辅助性T细胞17(Th17)改善自身免疫性甲状腺炎(AI... 李晓晖,赵卓,陈怡然,... - 《中国实验方剂学杂志》 被引量: 0发表: 2024年 石斛碱对IL-1β诱导的软骨细胞增殖和凋亡的影响及其机...
JunB is homogenously induced in activated CD4 T cells, and Junb deficiency severely impairs the clonal expansion of those cells in mice immunized with adjuvants that induce Th1, Th2 and Th17 responses. Like BATF and IRF4, JunB promotes cell survival through repressing apoptosis in Th1, Th2 ...
Viral myocarditisTh17 cellsIL-10B10 cells, a specific subset of regulatory B cells, are capable of regulating immune response and restricting inflammation and autoimmune disease progression by producing IL-10. B10 cells frequently change significantly during inflammation and autoimmunity. However, how B10...