fos基因家族由4个成员组成:fos、fosb、fosl1和fosl2。这些基因编码亮氨酸拉链蛋白,可与Jun家族的蛋白质二聚,从而形成转录因子复合物AP-1。因此,fos蛋白被认为是细胞增殖、分化和转化的调节因子。在某些情况下,fos基因的表达也与凋亡细胞死亡有关。The Fos gene f
homolog;Fos proto-oncogene, AP-1 trancription factor subunit;G0/G1 switch regulatory protein 7;activator protein 1;cellular oncogene c-fos;proto-oncogene c-Fos;transcription factor AP-1 subunit c-Fos;转录因子AP-1(AP-1);活化蛋白1(AP-1);激活子蛋白-1(AP-1);V-Fos-FBJ骨肉瘤病毒癌基因同源...
The AP-1 transcription factor subunit Fra-1 has been implicated in liver fibrosis. Here we have used loss-of-function as well as switchable, cell type-specific, gain of function alleles for Fra-1 to investigate the relevance of Fra-1 expression in cholestatic liver injury and fibrosis. Our ...
MiR-144-3p Targets FosB Protooncogene, AP-1 Transcription Factor Subunit (FOSB) to Suppress Proliferation, Migration, and Invasion of PANC-1 Pancreatic Can... Ding, "MiR-144-3p Targets FosB Pro- tooncogene, AP-1 Transcription Factor Subunit (FOSB) to Suppress Proliferation, Migration, and ...
The AP-1 is a transcription factor belonging to the c-Fos, c-Jun, activating transcription factor (ATF) and Jun dimerization protein (JDP) families and controls a number of cellular processes including differentiation, proliferation, and apoptosis. ...
c-Fos, a well known AP-1 transcription factor, has emerged as a unique protein with the capacity to associate to specific enzymes of the pathway of synthesis of phospholipids at the endoplasmic reticulum and activate their synthesis to accompany genomic decisions of growth. Herein, we discuss ...
小鼠核转录因子-1(AP-1)elisa检测试剂盒说明书Mouse AP-1 ELISA Kit 【实验用途】Ap-1是一类立早基因编码的核转录因子,其组成成员包括c-fos家族的c-fos,FosB,Fra-1,Fra-2与c-Jun家族的c-Jun,junB,JunD。这种转录因子主要由Jun、Fos、ATF及JDP亚家族组成,亚家族单体以同源或异源二聚体的形式结合DNA靶序列...
AP-1 transcription factor is a dimeric transcription factor encompassing a group of structurally and functionally related members of c-Jun, c-Fos, ATF, and MAF protein families [42,43,44] and it can therefore form many different combinations of heterodimers and homodimers, and this combination ...
Figure 5. Localization of AP-1 (Fos/Jun) and SMAD binding within region −335/−312 of the mGnRHR gene promoter. A. To further characterize and localize transcription factor binding, serial 2-bp mutant oligonucleotides of region −335/−312 of the mGnRHR gene promoter were prepared ...
The Fra-1/AP-1 transcription factor regulates the expression of genes controlling various processes including migration, invasion, and survival as well as extracellular remodeling. We recently demonstrated that loss of Fra-1 leads to exacerbated bleomyci