Antisense LncRNA常常位于蛋白编码基因两端,如Antisense LncRNA在转录起始位点上游250个核苷酸和基因有义链下游富集。由于Antisense LncRNA很少经历剪接事件,从而导致与正义转录物相比富集程度低。在不同组织和细胞系中,正义和反义转录本的表达水平可以呈正相关也可以呈负相关。此外,研究还发现,人细胞系Antisense LncRNA的表...
Antisense LncRNA常常位于蛋白编码基因两端,如Antisense LncRNA在转录起始位点上游250个核苷酸和基因有义链下游富集。由于Antisense LncRNA很少经历剪接事件,从而导致与正义转录物相比富集程度低。在不同组织和细胞系中,正义和反义转录本的表达水平可以呈正相关也可以呈负相关。此外,研究还发现,人细胞系Antisense LncRNA的表...
lncRNAncNATssurvivalBackground: Natural non-coding antisense transcripts (ncNATs) are long non-coding RNAs (lncRNA) transcribed from the opposite strand of a separate protein coding or non-coding gene. As such, ncNATs can increase overlapping mRNA (and the coded protein) levels by stabilizing ...
siRNA就是RNAi,与DNA配对可引导gene editing。 microRNA:早期方法和现有数据相结合或许是一个突破点。需要软件的局限性和偏向性。 piRNA:在低等和节肢动物中出现多。基因组上成簇存在,乒乓模型,调控翻译。 LncRNA: antisense RNAs:反RNA cis-NATs:两个位置在局部 trans-NATs两个位置在远处 如果需要功能互斥,则基因...
Here, we show that Pcdhα gene choice involves the activation of an antisense promoter located in the first exon of each Pcdhα alternate gene. Transcription of an antisense long noncoding RNA (lncRNA) from this antisense promoter extends through the sense promoter, leading to DNA demethylation ...
LncRNA AGAP2 antisense RNA 1 stabilized by insulin-like growth factor 2 mRNA binding protein 3 promotes macrophage M2 polarization in clear cell renal cell carcinoma through regulation of the microRNA-9-5p/THBS2/PI3K-Akt pathway Peng Xu, Da-xiong Feng, Jun Wang, Yao-Dong Wang, Gang ...
Natural antisense lncRNAs can interfere with their corresponding sense transcript to elicit concordant or discordant regulation. LncRNA ZNF667-AS1 and its sense gene ZNF667 were found to be downregulated in esophageal squamous cell carcinoma (ESCC) tissues by RNA sequencing; however, the exact roles ...
Recent efforts have revealed that numerous natural antisense lncRNAs play a crucial role in the regulation of cancer biology. Here, based on our previous study, we further identified that the lncRNA FOXC2-AS1 and its antisense transcript FOXC2 are positively up-regulated in doxorubicin-resistant os...
we elucidate the molecular mechanism by whichTRA2β-PEinclusion induces cancer cytotoxicity – not only through TRA2β protein downregulation, but, surprisingly, also by acting as a long noncoding RNA (lncRNA). Finally, we show the therapeutic efficacy of targetingTRA2β-PEinclusion in 3D organo...
Antisense oligonucleotides targeting lncRNA AC104041.1 induces antitumor activity through Wnt2B/β-catenin pathway in head and neck squamous cell carcinomas Mengwei Li, Xu Ding, Yinan Zhang, Xin Li, Haoze Zhou, Li Yang, Yilin Li, Peiwei Yang, Xiaomin Zhang, Jialiang Hu, Edouard...