反义和正义RNA二聚体的形成会影响到mRNA的核运输;此外,核内蛋白质或其他RNAs的相互作用会引起Antisense LncRNA在核内滞留,然而目前尚不明确其中的机制。Antisense LncRNA主要存在与细胞核内行使调节功能,诸如低氧、血清饥饿、过氧化物等细胞压力因子的存在会改变核内Antisense LncRNA的存在模式,从而改变相应正义RNA的水平。
反义和正义RNA二聚体的形成会影响到mRNA的核运输;此外,核内蛋白质或其他RNAs的相互作用会引起Antisense LncRNA在核内滞留,然而目前尚不明确其中的机制。Antisense LncRNA主要存在与细胞核内行使调节功能,诸如低氧、血清饥饿、过氧化物等细胞压力因子的存在会改变核内Antisense LncRNA的存在模式,从而改变相应正义RNA的水平。
Antisense LncRNA常常位于蛋白编码基因两端，如Antisense LncRNA在转录起始位点上游250个核苷酸和基因有义链下游富集。由于Antisense LncRNA很少经历剪接事件，从而导致与正义转录物相比富集程度低。在不同组织和细胞系中，正义和反义转录本的表达水平可以呈正相关也可以呈负相关。此外，研究还发现，人细胞系Antisense LncRNA...
lncRNAncNATssurvivalBackground: Natural non-coding antisense transcripts (ncNATs) are long non-coding RNAs (lncRNA) transcribed from the opposite strand of a separate protein coding or non-coding gene. As such, ncNATs can increase overlapping mRNA (and the coded protein) levels by stabilizing ...
Transcription of an antisense long noncoding RNA (lncRNA) from this antisense promoter extends through the sense promoter, leading to DNA demethylation of the CTCF binding sites proximal to each promoter. Demethylation-dependent CTCF binding to both promoters facilitates cohesin-mediated DNA looping ...
LncRNA: antisense RNAs:反RNA cis-NATs:两个位置在局部 trans-NATs两个位置在远处 如果需要功能互斥,则基因水平可以是这种结构,只能有一种蛋白质复合结构在序列上: 假基因:假基因一共可以分为三类:unitary pseudogene;duplicated pseudogene以及processed pseudogene。Unitary pseudogene是指蛋白质编码基因在进化过程中自身...
HOTAIR, an oncogeniclncRNA, has been shown to promote multiplepathological processesinvolvingcervical cancer, suggesting that this lncRNA may be a promising therapeutic target. Circulating HOTAIR is a candidate biomarker for early diagnosis of cervical cancer and an independent predictor of patients' pr...
LncRNA AGAP2 antisense RNA 1 stabilized by insulin-like growth factor 2 mRNA binding protein 3 promotes macrophage M2 polarization in clear cell renal cell carcinoma through regulation of the microRNA-9-5p/THBS2/PI3K-Akt pathway Peng Xu, Da-xiong Feng, Jun Wang, Yao-Dong Wang, Gang ...
Natural antisense lncRNAs can interfere with their corresponding sense transcript to elicit concordant or discordant regulation. LncRNA ZNF667-AS1 and its sense gene ZNF667 were found to be downregulated in esophageal squamous cell carcinoma (ESCC) tissu
Thus, we concluded that the lncRNA FOXC2-AS1 may promote doxorubicin resistance in OS by increasing the expression of transcription factor FOXC2, further facilitating ABCB1 expression. These findings demonstrate the potential underlying mechanism of FOXC2-AS1 in the regulation of doxorubicin resistance...