Most bacteria in nature exist in aggregated communities known as biofilms, and cells within a biofilm demonstrate major physiological changes compared to their planktonic counterparts. Biofilms are associated with many different types of infections which
of a specific metabolite produced byS. aureus, although the exact active molecule has yet to be identified. Additionally, in our study, the anti-biofilm effect of fucoidan was observed against bothA. baumanniiandS. aureus, in both single-species biofilm and dual-species biofilms. This finding ali...
While both forms were susceptible to disinfection by bleach, hydrogen peroxide and Virkon Aquatic, treatment with povidoneiodine did not eliminate biofilms. The ability of S. iniae to form resilient biofilms provides an effective mechanism for their persistence in the environment, which must be ...
Polyhexanide (PHMB) has a proven efficacy against pathogens commonly found in wounds, and has been recommended as a f... S Gilliver - 《Journal of Wound Care》 被引量: 19发表: 2009年 Antimicrobial ceragenins inhibit biofilms and affect mammalian cell viability and migration invitro The ...
(about 5000years old), has references to various types of microorganisms that cause diseases and stresses the need to destroy them to preserve human health. Many Ayurvedic drugs were known to be effective against common microbial infections such asMycobacterium tuberculosis(treated bySuvarna Bhasmaor ...
immunogen in a chinchilla animal model, with an established biofilm-associated infection, the resultant targeted immune response led to rapid resolution of the infection56. This strategy has also been shown to be effective when targeting polymicrobial biofilms within CF sputum solids57. Humanised ...
P. aeruginosa also expresses a number of virulence factors such as protease A, exotoxins, phospholipase C and cytotoxins for host cell invasion and pyoverdine and QS system regulatory proteins essential for the formation of biofilms, that plays a vital role in host immune evasion and antibiotic ...
It is undoubtable that at the present time, the oral drug ciprofloxacin and injection gentamicin are the most effective antibiotics against P. aeruginosa involved in wound infection relative to most other commonly used drugs. Pseudomonas resistant to third generation cephalosporins (ceftriaxone 63.6%) ...
Similarly, tigecycline (targeting CRE and CRAB)31,32, fluoroquinolones (broad spectrum antibiotic effective even against drug-resistant strains), aminoglycosides (to treat Gram-negative bacteria associated nosocomial pneumonia) and piperacillin/tazobactam (against multiple Gram-negative pathogens)33 are other...
Exploring the dynamics and molecular mechanisms of antimicrobial drug resistance provides critical insights for developing effective strategies to combat it. This review highlights the potential of experimental evolution methods to study resistance in pa