The acidic pH commonly found in bacterial biofilms favors the disintegration of ZIFs frameworks, causing an abundant release of metallic ions which can penetrate the biofilm and exert their antibiofilm effect [44]. This mechanism of metal-ion release is similar to ones previously reported for ...
"These properties make the bacteria more resistant to antibiotics and to the host's immune response. Certain antibiotics can penetratebiofilms, but their efficacy is usually greatly reduced. We generally need to increase the concentration of an antibiotic 10–1 000 times to get an effect equivalent...
(IMI ND4BB), a $280 million fund to support the clinical development of new antibiotics and conduct basic research into how antibiotics penetrate Gram-negative bacteria.15 Other incentives have also been proposed.16–19 In 2010, the Infectious Diseases Society of America launched the 10 Â '...
Moreover, it has been proven that many bacteria involved in nitrogen removal from wastewater or occurring in denitrifying systems, such asNitrospira,Ignavibacterium, andComamonasplay an important role as ARG-carrying bacteria. The role of anammox bacteria as hotspot of antibiotics resistance genes was ...
Antibiofilm research has introduced substances that interfere with quorum sensing, and affect enzymatic and peptide-mediated matrix dispersal. Nanotechnology will be used to penetrate the biofilm matrix as well as nanoetching to prevent biofilm development on surfaces. Management of contact lens keratitis ...
The diffusion channels in the biofilm matrix are around 500 nm wide, and nanoparticles could accumulate in the infection areas and penetrate into biofilms [15]. Nanoparticles with enzyme-mimetic activities have been used to catalytically break down the main components of EPS, such as exo...
if the biting lizard had an oral infection withE. lacertideformusand is able to penetrate the skin of the lizard they are biting, then this natural behaviour effectively replicates the skin laceration inoculation group in this study. Cannibalism of an infected gecko by an uninfected gecko could...
Any conditions that suppress a person's immune response create a higher risk for infection. Hospitalized people have a high risk of infection because of skin penetration by such things as intravenous lines, surgical incision sites, and implanted devices. Keeping penetrated skin sites clean and prote...
and target-specific investigations, have been employed to determine the factors affecting biofilm formation. However, the molecular pathways need to be clarified. Consequently, approaches that target biofilms could be useful in overcomingH. pyloridrug resistance (Roszczenko-Jasińska et al.2020; Abadi ...
to accumulate inside the cells and elicit the response. The optimum size of the ZnO NSs synthesized in this study could allow these nanostructures to penetrate cancer cells in high amounts and cause cell killing. Our study could conclude that at a higher dose of 100 μg/ml, both skin cance...