antimicrobial agentsP. aeruginosaheterogenicityBiofilms are communities of microorganisms attached to a surface. It has become clear that biofilm-grown cells express properties distinct from planktonic cells, one of which is an increased resistance to antimicrobial agents. Recent work has indicated that ...
Biofilms have been shown to be generally more resistant to antimicrobial chemotherapies than free-living bacteria. No current consensus exists regarding the mechanisms of biofilm resistance to antibacterial agents. Numerous competing theories are presently under investigation, yet the phenomenon of biofilm ...
One option is to use combinations of therapies, which use multiple drugs to limit resistance17. More desirable still would be the discovery of single strategies where resistance evolution never occurs, so called evolution proof strategies18. The notion of an evolution proof antimicrobial strategy is ...
K Lewis - 《Antimicrob Agents Chemother》 被引量: 3222发表: 2001年 Increased Antibiotic Resistance of Escherichia coli in Mature Biofilms Biofilms are considered to be highly resistant to antimicrobial agents. Several mechanisms have been proposed to explain this high resistance of biofilms, ... A ...
These results suggest that therapeutic strategies targeting sarA and/or sigB have the greatest potential to facilitate the ability to overcome the intrinsic antibiotic resistance that defines S. aureus biofilm-associated infections... DN Atwood,KE Beenken,TL Lantz,... - 《Antimicrobial Agents & Chem...
- 《Antimicrobial Agents & Chemotherapy》 被引量: 142发表: 2008年 Characterization of Plant-Derived Saponin Natural Products against Candida albicans Resistance to many clinically used antifungal agents has created a need to identify and develop a new generation of compounds for therapeutic use. A ....
Biofilms play an important role in the antibiotic drug resistance, which is threatening public health globally. Almost, all microbes mimic multicellular lifestyle to form biofilm by undergoing phenotypic changes to adapt adverse environmental conditions. Many anti-biofilm agents have been experimentally val...
Background Microbial biofilms pose a public health problem for persons requiring indwelling medical devices, as micro-organisms in biofilms are difficult to treat with antimicrobial agents. Thus the present study includes biofilm formation and antibiotic resistance pattern of uropathogens in hospitalised ...
Mechanisms of biofilm resistance to antimicrobial agents. Trends Microbiol 2001; 9: 34–39. Article CAS Google Scholar Anderson GG, O'toole GA . Innate and induced resistance mechanisms of bacterial biofilms. In: Bacterial Biofilms. Springer: Berlin, Germany, 2008, pp 85–105. Chapter Google ...
to form biofilm, defined as a bacterial aggregate colonizing solid–liquid interfaces8,9. Compared with planktonic cells, the bacteria embedded in a biofilm are 10–1,000 times more resistant to antimicrobial agents10,11,12. Biofilms ofS. maltophiliahave been found in various clinical settings and...