The purpose of this study was to investigate the proliferative and anti-inflammatory effects of Tremella fuciformis polysaccharide on osteoarthritis cell model human chondrocyte T/C-28a2. Methods: Proliferative effect and cytotoxicity of T/C-28a2 cells treated by Tremella fuciformis polysaccharide were ...
Temporomandibular joint osteoarthritis (TMJOA) is an inflammatory joint disease. This study investigated whether exosomes (Exos) of stem cells from human exfoliated deciduous teeth (SHEDs) have a therapeutic effect on TMJ inflammation and elucidated the
exosomes and microvesicles which are smaller than 0.22 µm and float at a density of < 1.2 g/ml, and hence represent small EVs. EV Concentration Protein was extracted from EV samples by lysing samples with cold radioimmunoprecipitation assay (RIPA) buffer (150 mM NaCl, 1.0% IGEPAL®,...
The therapeutic effects of mesenchymal stem cells-extracellular vesicles have been proved in many inflammatory animal models. In the current study, we aimed to investigate the effect of extracellular vesicles (EVs) derived from human umbilical cord-MSC (hUCSC-EV) on the clinical score and inflammato...
involvement of inflammatory cytokines in the pathogenesis of AMD. Corticosteroids play a unique role in the treatment of AMD by inhibiting the pro-angiogenic effects of inflammatory cytokines and targeting extracellular components of choroidal neovascularization [155], such as inflammatory cells and ...
The immunosuppressive effects of dexamethasone delivery via subconjunctival implants and via topical application have been shown to result in significant reduction of allograft rejection and neovascularization in rabbit models [29], however, to our knowledge this is the first time dexamethasone has been ...
Effects of exosomes from human dental pulp stem cells on the biological behavior of human fibroblasts Article Open access 07 January 2025 Development of secretome-based strategies to improve cell culture protocols in tissue engineering Article Open access 15 June 2022 Introduction...
An in vivo study349Exosomes from cardiomyocyte progenitor cells and mesenchymal stem cells stimulate angiogenesis in vitro and in vivo via EMMPRINEndothelium352Reciprocal regulation of GRK2 and bradykinin receptor stimulation modulate Ca2+ intracellular level in endothelial cells353The roles of bone ...
On the other hand, miR-155 may promote AS, as it has been observed to derepress BCL6-mediated inhibition of CCL2 transcription in the bone marrow cells of ApoE–/– mice19. These investigations have therefore demonstrated that miR-155 has opposite effects in different cell types, pathological...
pattern.n = 4.eSchematic diagram showed that Klotho in Osx+-mensenchymal progenitors exerts pro-osteogenic and anti-inflammatory effects during mandibular bone formation and repair. All data are shown as the mean ± SEM. Scale bar, 100 μm (a), 50 μm (b), and 10 μm...