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Anything that has the potential to help a medical condition also poses some risks of harm. For this reason, it’s important to discuss potential stem cell therapy side effects. In this case I am focusing on the risks primarily associated with unproven stem cell clinics. Not for established me...
An alleviant for the side effects caused by drugs, containing as the active ingredient at least one compound selected from the group consisting of malic, aspartic, tartaric, malonic, succinic, oxalic and tridecanoic acids as well as pharmaceutically acceptable salts thereof. It can alleviate side ...
Fibroblasts are cells of mesenchymal origin and are the main producers of ECM in homeostatic conditions and in response to injury5. These cells are found in virtually every tissue, but their molecular signature is not preserved between organs6. Fibroblasts are activated in the inflammatory stage of...
of multivesicular bodies. These internal vesicles are then released as exosomes. HSPs can directly translocate from the cytoplasm across the plasma membrane facilitated or not by ATP-binding cassette (ABC) transporters. Microvesicle shedding from the cell surface can also lead to the release of HSPs...
(6.25, 12.5, 25 mg/kg) also showed significant anti-inflammatory effects[20]. Its effect increased gradually, with a maximum edema inhibition rate of 49.80%[20]. More importantly, PHI also decreased the levels of IL-1β, IL-6, TNF-α, NO, and PGE2 in the carrageenan-induced paw ...
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To interrogate possible synergistic effects, combinations of different concentrations of the two drugs were used. Our data showed that Frondoside A decreased the viability of bladder cancer cells UM-UC-3 in a concentration-dependent manner, and its inhibitory effect on cell viability (2.5 μM) ...
While PAH resulted in a glycolytic shift, metabolomics discovered that the treatment with exosomes resulted in mitochondrial function and oxygen consumption improvement. The therapy with exosomes increased the expression of pyruvate dehydrogenase as well as of glutamate dehydrogenase 1 in pulmonary artery sm...
The transport of proteins between the different cellular compartments and the cell surface is governed by the secretory pathway. Alternatively, unconventional secretion pathways have been described in mammalian cells, especially through multivesicular bodies and exosomes. These highly sophisticated biological pr...