抗原刺激的。。。比如 antigen-experienced T cells,就是抗原刺激过的T 细胞！
B cells play a critical role in the pathogenesis of systemic lupus erythematosus (SLE). We analysed two independent cohorts of healthy donors and SLE patients using a combined approach of flow and mass cytometry. We have found that IgD-CD27+ switched and atypical IgD-CD27- memory B cells, ...
CD4lo??? T cells differentiate into effector T cells with enhanced expression of CD4 -???CD4hi??? effectors. Autoimmune diabetes-prone NOD mice display a unique set of antigen-experienced ???CD4lo??? T cells that persist after primary stimulation. Here, we report that a population of ...
cific CD8+ T cells. Expression of the senescence marker CD57 in antigen-experienced specific CD8+ T cells.Expression of the senescence marker CD57 in antigen-experienced specific CD8+ T cells.Egui, AdrianaCarmen Thomas, MCarrilero, Bartolomé...
Targeting B cells for the treatment of SLE: the beginning of the end or the end of the beginning? Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease for which therapeutic advances in immunosuppressive and support therapy have significan... I Calero,I Sanz - 《Discovery Medicine...
World Health Organisation recommends screening for the cryptococcal antigen (CrAg), a predictor of cryptococcal meningitis, among antiretroviral therapy (ART) nave people living with HIV (PLHIV) with CD4 <100 cells/mm 3. CrAg positivity among ART-experienced PLHIV with viral load (VL) non-...
Objective Synovial B cells play a critical role in rheumatoid arthritis (RA), being involved in autoantibody synthesis, T cell activation, and cytokine production. CXCL13 is a B cell chemoattractant that is instrumental in synovial B cell organization; the regulatory determinants of CXCL13 in ...
Cross linking of this complex with Abs directed against CD3 leads to potent activation of T cells. However, such activation is not Ag-specific. We exploited the observation that the TCR-CD3 complex is clustered on T cells that have been activated by Ag by using anti-CD3 nanoparticles to ...
In vitro generated anti-tumor T lymphocytes exhibit distinct subsets mimicking in vivo antigen-experienced cells. Cancer Immunol Immunother. 2011.Yang S, Luca G, Liu F, Ji Y, Yu Z, Restifo NP, Rosenberg SA, Morgan RA: In vitro generated anti-tumor T lymphocytes exhibit distinct subsets ...
Ag-experienced B cells including memory cells, plasmablasts, and Ab-secreting cells were expanded in the pediatric anti-NMDAR-AE cohort, but not in the controls. These Ag-experienced B cells in the cerebrospinal fluid of a pediatric case of NMDAR-AE that was refractory to treatment had ...