MHC class II signaling in antigen-presenting cells. Curr Opin Immunol. 2004; 16 (1):108–113. doi: 10.1016/j.coi.2003.11.006. [ Cross Ref ]Al-Daccak R, Mooney N, Charron D. MHC class II signaling in antigen-presenting cells. Curr. Opin. Immunol. 2004; 16 :108–113....
In other aspects, the disclosure relates to MHC class II-positive antigen presenting cells containing a specific regulator of Ii expression. Such cells are useful, for example, in the display of autodeterminant peptides in association with MHC class II proteins. Compositions of the invention find ...
which play a fundamental role in adaptive immunity. While MHC class I is ubiquitously expressed by almost all cells, MHC class II is mostly expressed by antigen-presenting cells (APCs) such as monocytes, macrophages, and
Epithelial cells expressing aberrant MHC class II determinants can present antigen to cloned human T cells Nature, 312 (1984), pp. 639-641 Google Scholar 52. M.E. Stein, M.J. Stadecker Characterization and antigen-presenting function of a murine thyroid-derived epithelial cell line J Immunol,...
THE number of specific complexes formed between peptide and the class II major histocompatibility complex (MHC) molecules expressed by an antigen-presenting cell (APC) after exposure to protein antigens is unknown, as is the number that activates T cells. Presentation of foreign peptides by APC ...
、抗原呈递细胞(Antigen-presentingcells,APC)是指能表达被特异性T细胞识别的MHC-抗原多肽复合体的任何细胞。通常是指能表达MHCII类分子的巨噬细胞(macrophage,M中)、树突状细胞(dendriticcells,DC)、B淋巴细胞等( ) A. 是 B. 否 相关知识点: 试题来源: ...
Major histocompatibility complex class II (MHCII) bound to a peptide antigen mediates interactions between CD4+ T cells and antigen-presenting cells. Targeting peptide–MHCII with T cell antigen receptors (TCRs) and TCR-like antibodies has shown promise
The meaning of ANTIGEN-PRESENTING CELL is any of various cells (such as a dendritic cell, macrophage, or B cell) that take up and process an antigen into a peptide fragment which when displayed at the cell surface in combination with a molecule of the ma
Antigenic peptide-loaded MHC class II molecules (peptide–MHC class II) are constitutively expressed on the surface of professional antigen-presenting cells (APCs), including dendritic cells, B cells, macrophages and thymic epithelial cells, and are presented to antigen-specific CD4+ T cells. The ...
E. Antigen presentation by interferon-γ-treated endothelial cells and fibroblasts: differential ability to function as antigen-presenting cells despite comparable Ia expression. J. Immunol. 135, 3750–3762 (1985). CAS PubMed Google Scholar Bland, P. MHC class II expression by the gut epithelium...