Serpins are a large family of highly homolog blood proteins but no direct interactions between the members have yet been observed in the String database (S-Fig. 7C). However, information found in another database of predicted human protein-protein interactions36 (http://www.compbio.dundee.ac...
We scanned the antigen-antibody complexes available in the PDB database by the MOE program36 to find structures with unique antibody sequences. 1479 antibody-antigen complexes (2958 heavy and light chains) were collected. The sequences were clustered using CD-HIT37 and redundant sequences with id...
A Somatic hypermutation in S-specific MBCs 2 weeks after boost 1 and 2. The number below represents the number of sequences included in the analysis at each timepoint. B Somatic hypermutation in Spike+ RBD+ and Spike+ RBD- MBCs 2 weeks after boost 1 and 2. The number below represents ...
The immunogen of PB9936 anti-Calcitonin/CALCA antibody is A synthetic peptide corresponding to a sequence at the C-terminus of human Calcitonin (83-119aa ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF), different from the related mouse and rat sequences by four amino acids. Could you tell me which ...
Antibody sequences were annotated using IgBlast (Ye et al., 2013) and SONAR (Schramm et al., 2016) against donor-specific gene database (see Antibody germline V gene identification section). Antibodies sharing both heavy and light chain V and J gene assignments and junction region were grouped...
DNA polymerase extends the 3' ends of primers around the circles, resulting in long, single stranded RCA products that remain attached to the complex. The RCA product, composed of tandem DNA repeats complementary to the circle sequence, is detected by hybridization with cyanine 5 (Cy5)-labeled...
celery: Asynchronous worker service(s) that process long-running tasks redis: In-memory database for storing celery queue tasks and results Running through Docker Compose is easiest in terms of setup, but web server autoreload is not supported, so you will have to restart the services after eac...
the payloads are coupled to the peptide via a click reaction. The peptide conjugation method has a series of advantages. Various payloads can be conjugated to antibodies, and their number can be controlled. Since the conjugation reaction is highly site-specific, and proceeds spontaneously, the st...
The invention provides improved non-human vertebrates and non-vertebrate cells capable of expressing antibodies comprising human variable region sequences. The present invention is directed to the provision of long HCDR3s from non-human vertebrates and cells. The present invention is also directed to ...
This invention provides compositions derived from polynucleotide sequences encoding the variable light and/or variable heavy regions of monoclonal anti-idiotype antibody 11D10, as well as polypeptides encoded thereby. The invention also provides compositions which can be used in the detection or treatment...