(1992). Aggregation behavior of antibody-carrying latex particles. J. of Colloid and Interface Science, 154(2): 393-399.Nakamura, M.; Ohshima, H.; Kondo, T., Electrophoretic behavior of antigen- and antibody- carrying latex particles. J. Colloid Interface Sci. 1992, 149, (1), 241-246...
At present, protein aggregation still remains a main area of focus in the production of monoclonal antibodies. Increasing the intrinsic properties of antibodies can promote manufacturability, attrition rates, formulation, safety, titers, immunogenicity, and solubility. On account of the ident...
The supernatant postagitation was analyzed using SE-HPLC, FTIR, and AUC analyses and revealed no changes in conformation and aggregation profile when compared to the nonagitated antibody sample. The antibody particles were comprised of a combination of nonnative intermolecular disulfide-linked covalent ...
所以抗体的重链和轻链之间正确配对非常关键。人源化抗体引起的抗体聚集沉淀反应(aggregation)通常会增加治疗性抗体的免疫原性,因此需要结合不同的方法来控制影响聚集的外部和内部因子,以减少免疫原性。人源化抗体在CDR移植后需要能保持和原抗体对抗原一致的...
人源化抗体引起的抗体聚集沉淀反应(aggregation)通常会增加治疗性抗体的免疫原性,因此需要结合不同的方法来控制影响聚集的外部和内部因子,以减少免疫原性。人源化抗体在CDR移植后需要能保持和原抗体对抗原一致的结合亲和力,且最近研究发现CDRs 和FWRs 也能影响到FcR结合(图2)。因此人源化抗体后要综合平衡各方面因素,...
AntibodyTherapeutics综述抗体⼈源化因素的综合考量近⽇，华⼈抗体协会旗下期刊、⽜津⼤学出版社出版的Antibody Therapeutics发表了新加坡 A∗STAR研究院 Samuel Ken-En Gan教授课题组关于抗体⼈源化需要考虑的要素和各要素作⽤ 的综述，原⽂标题为‘Sagacity in antibody humanization for therapeutics, ...
Protein aggregation is one of the most critical processes affecting protein solubility in various contexts-from protein therapeutics formulation to protein... Lowe,D. 被引量: 0发表: 2011年 Antibody therapeutics, antibody engineering, and the merits of protein stability Antibodies are highly soluble, ...
and aging. It contains three interglobular domains (IGDs), G1, G2, and G3 that are involved in aggregation, hyaluronan binding, cell adhesion, and chondrocyte apoptosis. Aggrecan fragments from articular cartilage are released into the synovial fluid at all stages of human osteoarthritis as a ...
人源化抗体引起的抗体聚集沉淀反应(aggregation)通常会增加治疗性抗体的免疫原性,因此需要结合不同的方法来控制影响聚集的外部和内部因子,以减少免疫原性。人源化抗体在CDR移植后需要能保持和原抗体对抗原一致的结合亲和力,且最近研究发现CDRs 和FWRs 也能影响到FcR结合(图2)。因此人源化抗体后要综合平衡各方面因素,...
Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 µm post-manufacturing filtered. 靶标信息 Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activ...