β-aggregation is the process of association of proteins, mainly via the formation of intermolecular beta-sheet structures through short aggregation-prone regions (APRs) of the polypeptide sequence. Although APRs are usually hydrophobic in nature, they need other key properties such...
(1992). Aggregation behavior of antibody-carrying latex particles. J. of Colloid and Interface Science, 154(2): 393-399.Nakamura, M.; Ohshima, H.; Kondo, T., Electrophoretic behavior of antigen- and antibody- carrying latex particles. J. Colloid Interface Sci. 1992, 149, (1), 241-246...
and aging. It contains three interglobular domains (IGDs), G1, G2, and G3 that are involved in aggregation, hyaluronan binding, cell adhesion, and chondrocyte apoptosis. Aggrecan fragments from articular cartilage are released into the synovial fluid at all stages of human osteoarthritis as a ...
An assay that measures the ability of serum to block haemagglutination, which is the aggregation (agglutination) of red blood cells caused by influenza virus. The resulting haemagglutination inhibition titre is a correlate of protection for influenza virus that is accepted by many regulatory agencies...
It contains three interglobular domains (IGDs), G1, G2, and G3 that are involved in aggregation, hyaluronan binding, cell adhesion, and chondrocyte apoptosis. Aggrecan fragments from articular cartilage are released into the synovial fluid at all stages of human osteoarthritis as a result of ...
Observations that anti-VEGF antibody-based therapeutics, such as aflibercept and bevacizumab, in complex with VEGF may facilitate platelet aggregation and thrombocyte activation through FcγRIIa in both human and transgenic murine model systems, highlights the importance of considering Fc-mediated effecto...
人源化抗体引起的抗体聚集沉淀反应(aggregation)通常会增加治疗性抗体的免疫原性,因此需要结合不同的方法来控制影响聚集的外部和内部因子,以减少免疫原性。人源化抗体在CDR移植后需要能保持和原抗体对抗原一致的结合亲和力,且最近研究发现CDRs 和FWRs 也...
PEGS Europe is the largest protein & antibody engineering conference, which has been described as "the best biologics technology meeting in Europe."
人源化抗体引起的抗体聚集沉淀反应(aggregation)通常会增加治疗性抗体的免疫原性,因此需要结合不同的方法来控制影响聚集的外部和内部因子,以减少免疫原性。人源化抗体在CDR移植后需要能保持和原抗体对抗原一致的结合亲和力,且最近研究发现CDRs 和FWRs 也能影响到FcR结合(图2)。因此人源化抗体后要综合平衡各方面因素,...
(2) The polar component imparts hydrophilicity to the inherently hydrophobic ADC, thus preventing aggregation and/or precipitation. (3) The trigger is the part of the linker that initiates cleavage and release of the drug. The three trigger mechanisms that have been exploited in the ADCs ...