An assay that measures the ability of serum to block haemagglutination, which is the aggregation (agglutination) of red blood cells caused by influenza virus. The resulting haemagglutination inhibition titre is a correlate of protection for influenza virus that is accepted by many regulatory agencies...
There is also a risk that one of the antibodies would be more prone to aggregation than the other component(s) and could act as a nucleating molecule that stimulates aggregation of the other antibodies in the cocktail. In addition, repeated antibody administrations (Palivizumab, e.g., is ...
Aggregation-resistant domain antibodies selected on phage by heat denaturation. Nat. Biotechnol. 22, 1161–1165 (2004). Article CAS PubMed Google Scholar Souriau, C., Chiche, L., Irving, R. & Hudson, P. New binding specificities derived from Min-23, a small cystine-stabilized peptidic ...
The immunoglobulin causes the aggregation of the Streptococcus.mutans, and it is preferable that the egg yolk is collected and purified to provide the objective antibody, because the IgG is particularly excellent in an effect inhibiting the adhesion of the Streptococcus.mutans to smooth surfaces. The...
Amyloid-β42 (Aβ42) aggregation consists of a complex chain of nucleation events producing soluble oligomeric intermediates, which are considered the major neurotoxic agents in Alzheimer’s disease (AD). Cerebral lesions in the brain of AD patients star
Aggregation-resistant domain antibodies selected on phage by heat denaturation. Nat. Biotechnol. 22, 1161–1165 (2004). Article CAS PubMed Google Scholar Sajadi, M. M. et al. λ Light chain bias associated with enhanced binding and function of anti-HIV Env glycoprotein antibodies. J. Infect...
Interactions between other parts of antibody molecules, such as the Fc regions, are thought to contribute to non-specific aggregation, cryoprecipitability, and to formation of precipitates of the immune complexes. These events are slower than the initial antigen–antibody interaction. Sign in to ...
Many of the cytotoxic drugs used in ADCs are hydrophobic and tend to induce antibody aggregation, which should be avoided to ensure a long shelf life and limit the use of the drug [141]. Increasing the hydrophilicity of cytotoxic metabolites, for example, through charged groups, can reduce ...
Familial Aggregation of Food Allergy and Sensitization to Food Allergens: A Family-Based Study Background The increasing prevalence of food allergy (FA) is a growing clinical and public health problem. The contribution of genetic factors to FA remain... HJ Tsai,R Kumar,J Pongracic,... - 《Cl...
J. Distinct aggregation mechanisms of monoclonal antibody under thermal and freeze-thaw stresses revealed by hydrogen exchange. Pharm. Res. 29, 236–250 (2012). PubMed Google Scholar Casaz, P. et al. Resolving self-association of a therapeutic antibody by formulation optimization and molecular ...