The need for new antibacterial drugs to treat the increasing global prevalence of drug-resistant bacterial infections has clearly attracted global attention, with a range of existing and upcoming funding, policy, and legislative initiatives designed to revive antibacterial R&D. It is essential to assess...
The need for new antibacterial drugs to treat the increasing global prevalence of drug-resistant bacterial infections has clearly attracted global attention, with a range of existing and upcoming funding, policy, and legislative initiatives designed to revive antibacterial R&D. It is essential to assess...
The fatty-acid side chains of the A54145 factors can be removed by a deacylase produced by Actinoplanes utahensis,6 thus providing a means to generate the peptide core as a starting material for chemical acylations with different fatty acids.7 Several semisynthetic derivatives were tested for ...
roseosporus harboring a deletion of dptD. All constructs successfully complemented the deletion in trans, generating three peptide cores related to daptomycin. When these were coupled with incomplete methylation of 1 amino acid and natural variation in the lipid side chain, 18 lipopeptides were ...
Factors Associated With Nonadherence to Antibiotic Administration Guidelines In adjusted analyses (Table 3), we found that emergency surgery (OR, 1.35, 95% CI, 1.29-1.41; P < .001), procedures starting during off-hour shifts (ie, not between 6:30 am and 5:00 pm) (OR, 1.08; 95% ...
A reduction in antimicrobial activity may not be adequately demonstrated by chemical methods. This chapter summari- zes procedures for the antibiotics recognized in the United States Pharmacopeia ( USP) for which the microbiological assay is the standard analytical method. Two general techniques are ...
“It would be like reading a sentence starting at the middle of each word and joining it to the first half of the next word to produce a string of gibberish,” Freimuth said. The gibberish protein reminded Freimuth of a class of antibiotics called aminoglycosides. These a...
dichloropyrideasstartingmaterialcompound8was obtained after four step reactions (Scheme 1).The structure of 8 w a s confi rm ed b v H N M R ”C N M R an d M S analy sis.D uring the sy nthe sis of c om pound 9 it w as f ou nd w he n ...
aDue to their relatively high reactivity, the SH end groups of thiocols served also as starting points for the preparation of various 由于他们的相对地高反应性, SH末端小组thiocols也担[translate] a我相信这是他应该获得的 I believed this is he should obtain[translate] ...
While the overall numbers are still low compared to other therapeutic disease indications, the clinical pipeline is now starting to resemble the more traditional progression Compounds and BLI combinations by phase and derivation 25 NP-derived (16) NP-BLI (1) 20 P-derived (4) S-derived (32) ...