Davis R.L.Briggs G.M.Poultry ScienceDavis, R. L., and G. M. Briggs, 1951. Studies with antibiotics in chick and poult starting rations. Poultry Sci. 30: 767-771.Davis R. L. and Briggs G. M. (1954) Studies with antibiotics in chick and poults starting rations. Poultry Sci. 30,...
If the blood culture of the described baby remained negative, the physician may still conclude that starting antibiotics was the right decision due to the possibility of culture-negative EOS. But culture-negative EOS is a controversial diagnosis, without clear diagnostic criteria and there is a ...
with cytoskyrin A433 and 2,2′-epi-cytoskyrin A.432,434 The developed synthetic strategy toward this novel structure involved two of the simplest reagents (that is, MnO2 and CF3COOH) and proceeded smoothly under thermal conditions (25–45 °C). Starting from dihydroanthracenone building ...
threatening global health. The adverse impact of drug-resistant infections is highlighted by a seminal analysis of the global burden of bacterial antimicrobial resistance in 2019, with 1.27 million deaths directly attributed to, and 4.9 million deaths ...
Semi-synthetic antibiotics generally have fewer impurities than their biological counterparts. Impurities may include fermented starting material with related impurities, synthesis by-products, synthesis intermediates, and degradation products. Beta-lactam antibiot...
dialysis solution, mimicking three clinically relevant scenarios: (i) target-controlled dialysis in a subject with sub-therapeutic drug levels, (ii) target-controlled dialysis in a subject with supra-therapeutic drug levels, and (iii) traditional dialysis of drugs starting at the target concentration...
In the United Kingdom (UK), the Pharmaceutical Quality Assurance Committee of the National Health Service defines a value of 95–105% of the starting concentration of the “active pharmaceutical ingredient” (API) [8]. Other jurisdictions do not provide guidance on this matter with values >...
The need for new antibacterial drugs to treat the increasing global prevalence of drug-resistant bacterial infections has clearly attracted global attention, with a range of existing and upcoming funding, policy, and legislative initiatives designed to r
Future antibiotics scenarios: is the tide starting to turn? Int. J. Antimicrob. 34, 15–20 (2009). Article CAS Google Scholar Demain, A. L. Microbial natural products: alive and well in 1998. Nat. Biotechnol. 16, 3–4 (1998). Article CAS Google Scholar Demain, A. L. & Adrio,...
The procedure of Example 17 is again repeated, starting with the requisite reagents, to provide the following penicillin analogs: 6-[D-2-phenyl-2-(N-{o-chlorobenzimidoyl}N-methylaminoacetamido)acetamido]p enicillanic acid, 6-[D-2-phenyl-2-(N{N'-ethyl-m-fluorobenzimidoyl}aminoacetamido]pe...