Though antibiotic-impregnated cement is considered safe in terms of nephrotoxicity, two cases that have implicated aminoglycoside-impregnated cement in acute renal failure (ARF) after surgery for an infected total knee arthroplasty (TKA) have been reported [Curtis et al. 2005, Van Ra...
of aminoglycosides and polymyxins may result inrenal toxicity; of daptomycin may result in high phosphokinase levels and muscle aches. Patients who requirehemodialysisshould be carefully managed; reference to appropriate guides regarding administration and dosing of antibacterial agents is strongly recommended...
New molecular diagnostic tools may be of interest for decreasing the antibiotic consumption in specific populations, mainly patients with suspected lower respiratory tract (LRT) infections. Razazi et al. evaluated the FilmArray Pneumonia plus Panel, a multiplex polymerase chain reaction (mPCR) assay, in...
Renal lesions and manifestations: HIV-associated nephropathy and genitourinary tract infections. 9. Hepatobiliary lesions and manifestations: Factors that are responsible are the development of coinfection with hepatitis B or C or other infectious and drug-induced hepatic toxicity. The hepatic les...
in the duration of antibiotic therapy. However, these trials present several limitations, namely high rate of patients’ exclusion, high rate of algorithm overruling, long duration of antibiotic therapy in the control group, disregard the effect of renal failure on PCT level, and above all a ...
infec- tion (respiratory, urinary tract, abdominal, skin or central nervous system), sepsis-3 definition or severity of sepsis (defined by either the sequential organ failure assessment [SOFA] score, the presence of septic shock or renal failure, or the need for vasopressor or ventilatory ...
Although there has been substantial improvement in the urological management, urinary tract infection and deterioration in renal function is still a major cause of morbidity and mortality in these patients (Grundy and Russell, 1986). The early management of patients in a spinal injury unit generally...
Practical Tip: Antibiotic pharmacokinetics during CRRT is highly variable, and dosing regimens relevant to institutional practice should be established locally. Current data suggests that beta-lactam dosing should be similar to that employed in patients without renal failure in the first 48hrs of treatme...
should always be used with once- or twice-weekly drug levels and assessment of renal function.Amphotericin B, the aminoglycosides, and semisyntheticpenicillinspreviously were used much more frequently but have now fallen out of favor because of alternative therapeutic strategies.53The OPAT registry docu...
PCT appears in the blood several hours after the inflammatory insult, reaches its maximum at ca. 12 h and persists for several days thereafter [5], [6]. Importantly, the kinetics of PCT are not affected by renal insufficiency or renal replacement therapy [7], [8], [9]. Elevated PCT ...