Kidney failure related to broad-spectrum antibiotics in critically ill patients: secondary end point results from a 1200 patient randomised trialObjectives To explore whether a strategy of more intensive antibiotic therapy leads to emergence or prolongation of renal failure in intensive care patients.BMJ...
in the individual patient are determined, using therapeutic drug monitoring, with subsequent dose adjustment, to achieve pharmacodynamic end points that have been correlated with efficacy.If mortality in patients with acute renal failure is increasing because of antibiotic underdosing, as suggested by Dr...
However, these trials were halted due to adverse events — an increase in serum creatinine and acute kidney injury in the nosocomial pneumonia trial in 2019 [273]. TXA709 (50) (po) is an anti-MRSA prodrug of TXA707 (51) that has been evaluated in a phase-I trial conducted by TAXIS...
Intensive care unit (ICU) patients present several unusual pharmacokinetic (PK) characteristics compared with less seriously ill patients, including increased distribution volume and variable clearance. Interpatient PK variability is often considerable and can produce a wide range of values for PK parameter...
Kidney Int 56:S24–S28. https://doi.org/10.1046/j.1523-1755.56.s.72.2.x Article Google Scholar Broeker A, Vossen MG, Thalhammer F et al (2020) An integrated dialysis pharmacometric (IDP) model to evaluate the pharmacokinetics in patients undergoing renal replacement therapy. Pharm Res 37...
Absorption of antibiotics during peritoneal dialysis in patients with renal failure These studies were made in patients with advanced renal failure awaiting kidney transplantation and having nightly peritoneal dialysis. " Some " of them ha... AC Buck,SL Cohen - 《Journal of Clinical Pathology》 被引...
- 《American Journal of Kidney Diseases》 被引量: 97发表: 1993年 Tuberculous peritonitis in patients undergoing continuous ambulatory peritoneal dialysis: case report and review. A case of tuberculous peritonitis complicating continuous ambulatory peritoneal dialysis (CAPD) in a 37-year-old man who ...
1.5-2 h N/A kidney (urine) Contraindications and Cautions The following are contraindications and cautions for the use of other antibiotics: Ketolides: telithromycin with antiarrhythmics and antilipidemics can cause serious adverse effects. It might also cause potentially fatal respiratory failure in ...
The polymyxins are not widely used because they are toxic to the kidney and to the nervous system.18, 19, 20 The latest antibiotic launched in 2006 by Merck (platensimycin) has different mechanism of action from the previous ones, since it acts by inhibiting the beta-ketoacyl synthases I ...
Those with medication allergies, reduced liver or kidney functions, or women who are pregnant or breastfeeding should take antibiotics with extreme caution. Patients taking antibiotics should not take any other medications, or herbal medicines, without first consulting a doctor. Over-the-counter medicin...