As for meropenem, this drug is regarded as one of the safer carbapenems (9) due to its stabil- ity to renal dehydropeptidase-I (10), which was confirmed in a large clinical trial (11). Although these alternatives to gentami- cin appear quite safe, information on the potential toxic ...
Normally no cross reaction with Penicillin, in some cases of renal failure > nephrotoxic 15-20 mg/kg SC bid, tid 20 mg/kg SC sid Chloramphenicol Exceptionally leads to a decreased appetite 30-50 mg/kg PO, SC, IM bid 15 mg/kg PO bid Chlortetracycline . 50 mg/kg PO...
Penicillins are generally very safe drugs with minimum toxicity. Their most common side effect is diarrhea. Nausea, vomiting, and upset stomach are also common. In rare cases penicillins can cause immediate or delayed allergic reactions which manifest as skin rashes, fever, angioedema, and anaphyla...
A pilot randomized clinical trial (RCT) comparing seven days of dornase alfa to sham therapy in 11 preterm infants aged zero to four months with ventilator-associated RTI found dornase alfa to be safe and associated with an improvement in supplemental O2 requirement, although this did not reach...
The recommended dosage of doripenem is 500 mg i.v. every 8 hours infused over 4 hour. The dosage should be decreased in patients with moderate renal impairment [35]. Recently, the EMA has given new advice for the treatment of patients with HAP. A review of available data raises concerns...
No significant differences were found in persistent renal damage at 6 months (2 studies, 424 children: RR 0.87, 95% CI 0.35 to 2.16) or in duration of fever (2 studies, 693 children: WMD 1.54, 95% CI -1.67 to 4.76) between oral antibiotic therapy (10 to 14 days) and IV therapy (...
There is growing global recognition that the continued emergence of multidrug-resistant bacteria poses a serious threat to human health. Action plans released by the World Health Organization and governments of the UK and USA in particular recognize that
When antibacterials are used in neonates, accurate determination of dosage is required, particularly for compounds with a low therapeutic index and in patients with renal failure. Very low birthweight infants are also particularly prone to antibacterial-induced toxicity....
Dalbavancin (3) has an extended half-life of over 300 h in humans,54 allowing for a significant dosing advantage over the twice-daily dosing required for vancomycin. The current prescribing information (Jan 2016) provides for two dosage regimes with different doses depending on renal function: ...
aminoglycoside ear is the most important adverse renal toxicity in patients with renal insufficiency, the first third-generation cephalosporins have varying degrees of half-life extension, medication should cause the clinician’s attention. Liver toxicity [6] such as: amphotericin B and lincomycin can ...