Development of new biocides has dominated human responses to evolution of antibiotic and pesticide resistance. Increasing and uniform biocide use, the spread of resistance genes, and the lack of new classes of
The spread of antibiotic resistance is attracting increased attention to combination-based treatments. Although drug combinations have been studied extensively for their effects on bacterial growth1,2,3,4,5,6,7,8,9,10,11, much less is known about their effects on bacterial long-term clearance, ...
resistance was weak compared to selection, leading to the emergence of a highly structured meropenem resistant pathogen population1,2,3,49. We speculate that the high in vivo mutation rate ofPseudomonaswas key to shaping local adaptation to antibiotic selection across tissues, and that within-host ...
When strong selection for resistance is generated by a combined antibiotic treatment (for example, for synergistic combinations) and resistance evolves, the cost of more effective individual treatment is borne by the public in the form of long-term loss of treatment options and more recalcitrant futu...
1b), at which point the selection was stopped. We isolated three individual clones from each of the evolved populations that had significantly higher persistence rates (most showed a more than 1,000-fold increase), but similar resistance, compared to the parental strain. Most of the evolved ...
Antibiotic binding sites are located in important domains of essential enzymes and have been extensively studied in the context of resistance mutations; however, their study is limited by positive selection. Using multiplex genome engineering1 to overcom
EURIS (European Resistance Intervention Study) was launched as a multinational study in September of 2000 to identify the multitude of complex risk factors that contribute to the high carriage rate of drug resistant Streptococcus pneumoniae strains in children attending Day Care Centers in several Europe...
Pathogens belonging to the Enterobacteriaceae family were observed to undergo directional selection developing resistance against antibiotics ciprofloxacin, piperacillin-tazobactam, cefepime, and cefuroxime. Pathogens in the surgical ward exhibited higher levels of antibiotic resistance, while non...
Antibiotic drug resistance Nano-device Nano-robots Nano-antibiotics Nano-materials Abbreviations CDC Centers for Disease Control and Prevention WHO World Health Organization XDR-TB Extensively drug-resistant TB MDR-TB Multidrug-resistant tuberculosis PM Plasma membrane NPs Nanoparticles TLR Toll-like receptors...
The release of antibiotics into the environment and the exposure of the entire microbial system to unprecedented antibiotic selection pressures can lead to the development of microbial resistance, especially among pathogenic and conditionally pathogenic bacteria, which is increasing and greatly hinders the ...