Pathogens belonging to the Enterobacteriaceae family were observed to undergo directional selection developing resistance against antibiotics ciprofloxacin, piperacillin-tazobactam, cefepime, and cefuroxime. Pathogens in the surgical ward exhibited higher levels of antibiotic resistance, while non...
resistance was weak compared to selection, leading to the emergence of a highly structured meropenem resistant pathogen population1,2,3,49. We speculate that the high in vivo mutation rate ofPseudomonaswas key to shaping local adaptation to antibiotic selection across tissues, and that within-host ...
In addition to its importance in combating clinical resistance2,3,4, the study of antibiotic resistant mutants has also advanced our understanding of fundamental biological processes5. Because antibiotics function by targeting enzymes necessary for bacterial survival, resistance mutations have been instrument...
The spread of antibiotic resistance is attracting increased attention to combination-based treatments. Although drug combinations have been studied extensively for their effects on bacterial growth1,2,3,4,5,6,7,8,9,10,11, much less is known about their effects on bacterial long-term clearance, ...
which creates antibiotic selection pressure that has driven the development and rising prevalence of antibiotic resistantCampylobacter. This is particularly evident with the resistance to fluoroquinolone (FQ), which has become a great concern for public health. However, the increased prevalence of antibioti...
Such treatment aggravates the risk of the emergence of multidrug resistance and jeopardizes gut microbes' physiology [11]. These antibiotic regimes inhibit intracellular signaling proteins (or enzymes), hamper the nucleic acid synthetic pathways (DNA or RNA), and suppress cell wall formation. However...
Development of new biocides has dominated human responses to evolution of antibiotic and pesticide resistance. Increasing and uniform biocide use, the spread of resistance genes, and the lack of new classes of compounds indicate the importance of navigating toward more sustainable coevolutionary dynamics...
Such endeavors are extremely important in light of widespread resistance to antibiotics and the decreasing number of new antibiotics developed through traditional means29. Methods Construction of strains. Strain Sc.A1 was made by replacing the TRP1 gene in BY4741 with the pcbAB-npgA segment from ...
Multidrug-resistant Acinetobacter baumannii, a major hospital-acquired pathogen, is a serious health threat and poses a great challenge to healthcare providers. Although there have been many genomic studies on the evolution and antibiotic resistance of t
Postoperative infections represent a significant burden of disease, demanding antibiotic prescriptions, and are contributing to antimicrobial resistance. The burden of infection as a surgical complication is greater in low- and middle-income countries (LMICs). We report the protocol of a pilot study for...