2009. AbaR5, a large multiple-antibiotic resistance region found in Acinetobacter baumannii . Antimicrob. Agents Chemother . 53 :2667–2671Post V, Hall RM. AbaR5, a large multiple-antibiotic resistance region found in Acinetobacter baumannii . Antimicrob Agents Chemother. 2009; 53 (6):2667–2671...
Antibiotic-resistant bacteria are causing a global health crisis. Here, the authors review recent advances in our understanding of the mechanisms by which bacteria are either intrinsically resistant or acquire resistance to antibiotics. This information
There are two mechanisms of resistance. The first is mediated by target mutations in the quinolone resistance-determining region of gyrA and gyrB, and in the parC subunit of topoisomerase IV. The second involves alterations in the expression of the qnr efflux system, and an aminoglycoside ...
Recommended statistics Overview Consumption of antibiotics and cost Antibiotic misuse Antimicrobial resistance Opinions and habitsKey insights Percentage of Italians who used oral antibiotics in 2022 Italian region with the highest use of antibiotics Cases of bacteremia caused by antibiotic-resistant bacte...
Cryptic pockets have been investigated to address antibiotics resistance caused by mutations in 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK), UDP-diacylglucosamine pyrophosphohydrolase (LpxH), falcipain-2 (FP-2), dihydropteroate synthase (DHPS), filamentous thermosensitive protein Z (...
A unique, protective cell envelope contributes to the broad drug resistance of the nosocomial pathogen Acinetobacter baumannii. Here we use transposon insertion sequencing to identify A. baumannii mutants displaying altered susceptibility to a panel of diverse antibiotics. By examining mutants with antibioti...
(African region, region of the Americas, Eastern Mediterranean region, European region, South-East Asia region, and Western Pacific region). ForK. pneumonia, the six WHO regions had more than 50% resistance to third-generation cephalosporins and two WHO regions had more than 50% resistance to ...
The WHO GAP for antimicrobial resistance sets out a road map of activities necessary to combat ABR [3]. Moreover, recommendations and road maps for the containment of ABR have been drawn by policy makers (e.g. Public Health England), the scientific community and other international initiatives...
Cross-resistance to drugs with other action mechanisms was also observed, as in the case of the beta-lactam resistance exhibited by the CP- and ENX-resistant strains. One possible cause of the observed cross-resistance is that the resistance acquisitions to these drugs shared the same mechanisms...
The worldwide emergence of antibiotic resistance poses a serious threat to human health. A molecular understanding of resistance strategies employed by bacteria is obligatory to generate less-susceptible antibiotics. Albicidin is a highly potent antibact