A desire to monitor, model and predict antibiotic resistance has resulted in the development and use of surveillance systems at the local level (primarily hospital-based systems), as well as regionally, nationally and internationally. Antibiotic resistance presents an ongoing challenge in the effective...
Antibioticresistance is recognised as a major global threat topublic healthby the World Health Organization. Currently, several hundred thousand deaths yearly can be attributed to infections with antibiotic-resistant bacteria. The major driver for the development ofantibioticresistance is considered to be ...
Our understanding of the molecular mechanisms of resistance has recently increased as a result of advances in systems biology, genomics and structural biology. New knowledge about antibiotic resistance should be used to inform the design of novel therapeutic agents that might not be subject to, or ...
Landecker, H. (2015) Antibiotic resistance and the biology of history. Body & Society, 1-34.Antibiotic Resistance and the Biology of History. Body & Society. Published online before print March 13,Landecker H. 2015. Antibiotic Resistance and the Biology of History. Body Soc 22:1-34....
Most antibiotic resistance mechanisms are associated with a fitness cost, which is a key biological parameter that influences the development of resistance. The fitness cost is the main driver of resistance reversibility at the community level. Thus, the bigger the fitness cost, the faster the rever...
Due to the prevalence of infections and outbreaks caused by multi-drug resistantA. baumannii, few antibiotics are effective for treating infections caused by this pathogen. To overcome this problem, knowledge of the pathogenesis and antibiotic resistance mechanisms ofA. baumanniiis important. In this ...
Tackling antibiotic resistance necessitates deep understanding of how resource competition within and between species modulates the fitness of resistant microbes. Recent advances in ecological coexistence theory offer a powerful framework to probe the mechanisms regulating intra- and interspecific competition, ...
The increasing prevalence of antibiotic-resistant bacteria has become a notorious threat to human health. Bacteria become resistant through resistance genes that can move between cells using horizontal gene transfer. Antibiotics are naturally produced by microorganisms in the environment and therefore bacteria...
Bacterial antibiotic resistance is a global health concern of increasing importance and intensive study. Although biofilms are a common source of infections in clinical settings, little is known about the development of antibiotic resistance within biofi
It has become increasingly clear that low levels of antibiotics present in many environments can select for resistant bacteria, yet the evolutionary pathways for resistance development during exposure to low amounts of antibiotics remain poorly defined.