Metagenomic sequencing represented a powerful alternative to rRNA sequencing for analyzing complex micro- bial communities [20,28] and has a tremendous impact on the study of microbial diversity in environmental and clinical samples. Nowadays, the field of metagenomics can roughly ...
Antibiotic resistance is an imminent threat to the effective treatment of bacterial infections, and alternative antibiotic strategies are urgently required. The golden epoch of antibiotics is coming to an end, and the development of new therapeutic agents to combat bacterial infections should be prioritiz...
These approaches have the potential to stem the tide of resistance by expanding the physicochemical property space and target spectrum occupied by currently approved antibiotics.In this Review, Tan and colleagues highlight recent efforts to discover non-traditional antimicrobials and explore the therapeutic...
aeruginosa is a recently characterized mechanism, which includes biofilm-mediated resistance and formation of multidrug-tolerant persister cells, and is responsible for recalcitrance and relapse of infections. The discovery and development of alternative therapeutic strategies that present novel avenues against...
In the face of rising antibiotic resistance, antibiotic efficacy seems to be progressively diminishing, so alternative approaches to antibiotics are highly recommended. The use of nanotechnology in medicine is developing rapidly, and it is not surprising to see these technologies being practically used ...
S2). Seven resistance-associated variants were identified in the alternative activating enzymes for ethionamide, Rv3083 (5) and Rv0565c (2), and three resistance-associated variants were found in the non-canonical ethionamide gene mshA. The relative lack of mutations with significant effects ...
on the population structure. This population structure could be leveraged to offer an alternative approach to detecting resistance whereby rather than detecting high-risk genes, we identify high-risk strains. While many approaches have been developed to identify whether a pathogen carries mutations or ...
Causesanincreaseinthedevelopmentofresistance. Animportantsocialchangeistheincreaseinthe numberofpeoplewhoareimmunocompromised. ›Necessitatesincreaseduseofantibiotics ›Fostersdevelopmentofresistance Emergingandre-emergingdiseasesareanother sourceforresistance. ...
Alternative therapeutic strategies to treat antibiotic-resistant pathogens Article 11 December 2023 Molecular mechanisms of antibiotic resistance revisited Article 21 November 2022 Using next generation antimicrobials to target the mechanisms of infection Article Open access 22 September 2023 Change...
W. et al. Evaluation of machine learning and rules-based approaches for predicting antimicrobial resistance profiles in Gram-negative Bacilli from whole genome sequence data. Front. Microbiol. 7, 1887 (2016). Article PubMed PubMed Central Google Scholar Boulund, F., Johnning, A., Pereira, M...