Clinical Disorders Therapeutic Classes Mechanism Classes Class III Antiarrhythmics (Potassium Channel Blockers)General Pharmacology All class III antiarrhythmic drugs share a common electrophysiological mechanism in that they prolong the action potential duration, and most of the drugs in this class do so ...
ACLS pointers: Understanding classes of antiarrhythmicsKeep this chart handy for sorting out the seven drug classes in advanced cardiac life support.Nursing
The goal of this study was to identify compounds that block the Ca(v)3.2 T-type channel with high affinity, focusing on two classes of compounds: phenylalkylamines (e.g., mibefradil) and dihydropyridines (e.g., efonidipine). Compounds were tested using a validated Ca(2+) influx assay ...
Amiodarone and class Ic antiarrhythmics are more effective than other classesInpharma Weekly -doi:10.2165/00128413-199007520-00031NoneSpringer International PublishingInpharma Weekly
Beta-adrenergic receptor blockers represent a heterogeneous class with more than 50 years of continuous development. Beta-blockers are one of the most used therapeutic classes and their efficacy was proven in a wide range of cardiovascular diseases, including arrhythmias, in both acute and chronic ...
The use of all classes of antiarrhythmic agents decreased from 61% to 24% during this time period (P < 0.05), In addition, there was a significant reduction in antiarrhythmic agent use for each drug class (P < 0.05) with the exception of Class II agents (beta blockers). These changes ...
Depending on how it affects the electrophysiologic properties of the heart, every antiarrhythmic belongs to one of four classes. Once you understand the common characteristics of each antiarrhythmic class, you can zero in on the specific features that make a medi...
This chapter discusses the chromatographic procedures applied to the analysis of a number of selected drugs or classes of drugs, which are toxicologically relevant. The chapter guides through the separation methods employed both in the sample preparation and in the final analysis, by demonstrating ...
A channel model has been taken containing pore region glutamates and all three classes' sensing residues. Benzothiazepine drugs have been docked in and ternary complex (that is, drug …Ca 2+… channel model) stability has been studied and related to mechanistic aspects of these drugs....
The highest level of antiarrhythmic activity and the lowest toxicity were obtained with compound N-[2-(adamant-2-yl)aminocarbonylmethyl]-N-[3-diethylamino]propyl]-4-nitrobenzamide, which also had the advantage of a wider therapeutic ratio over known antiarrhythmic drugs of classes I, IV, and ...