mice.#We observed that exposure to amlodipine (a calcium channel blocker), atenolol (a class II antiarrhythmic), and amiodarone (a class III antiarrhythmic) led to dose-dependent reductions in heart rate in zebrafish embryos, with effects varying based on drug concentration and mechanism of action...
In 2022, the "Inter-Society Guideline for the Manage- ment of Multimorbidity and Polypharmacy" was published in the National Guidelines System of the Italian National Institute of Health, outlining, among other topics, the gen- eral principles for deprescribing specific drug classes (i.e., anti...
Pazopanib determines QT prolongation (>500 ms) in 2% of cases. The incidence of TdP is <1% [26]. It must be used with caution in patients with heart disease or who are taking antiarrhythmics or other drugs known to prolong the QT. Sunitinib and sorafenib Sunitinib is a multi-targeted...
blockers, calcium channel antagonist, or calcium antagonists. The calcium channel blockers possess broad pharmacological use and they exhibit pronounced properties such as long-lasting vasodilating effects accompanied by an energy-sparing effect on cardiac metabolism, antiarrhythmic and antianginal action ...
Although there were a few sets of examples used for training and testing, because every subject is just an example it is apparent that the classification accuracy varies from 60 to 100% when using the five original classes and the whole VF episodes. In particular, Table 4 presents two results...
Although there were a few sets of examples used for training and testing, because every subject is just an example it is apparent that the classification accuracy varies from 60 to 100% when using the five original classes and the whole VF episodes. In particular, Table 4 presents two results...